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dc.contributor.authorSchumacher, Julia
dc.contributor.authorPeraza, Luis R
dc.contributor.authorFirbank, Michael
dc.contributor.authorThomas, Alan J
dc.contributor.authorKaiser, Marcus
dc.contributor.authorGallagher, Peter
dc.contributor.authorO'Brien, John T
dc.contributor.authorBlamire, Andrew M
dc.contributor.authorTaylor, John-Paul
dc.date.accessioned2018-11-13T00:30:27Z
dc.date.available2018-11-13T00:30:27Z
dc.date.issued2018-03
dc.identifier.issn1065-9471
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284951
dc.description.abstractDementia with Lewy bodies (DLB) is a common form of dementia and is characterized by cognitive fluctuations, visual hallucinations, and Parkinsonism. The phenotypic expression of the disease may, in part, relate to alterations in functional connectivity within and between brain networks. This resting-state study sought to clarify this in DLB, how networks differed from Alzheimer's disease (AD), and whether they were related to clinical symptoms in DLB. Resting-state networks were estimated using independent component analysis. We investigated functional connectivity changes in 31 DLB patients compared to 31 healthy controls and a disease comparator group of 29 AD patients using dual regression and FSLNets. Within-network connectivity was generally decreased in DLB compared to controls, mainly in motor, temporal, and frontal networks. Between-network connectivity was mainly intact; only the connection between a frontal and a temporal network showed increased connectivity in DLB. Differences between AD and DLB were subtle and we did not find any significant correlations with the severity of clinical symptoms in DLB. This study emphasizes the importance of reduced connectivity within motor, frontal, and temporal networks in DLB with relative sparing of the default mode network. The lack of significant correlations between connectivity measures and clinical scores indicates that the observed reduced connectivity within these networks might be related to the presence, but not to the severity of motor and cognitive impairment in DLB patients. Furthermore, our results suggest that AD and DLB may show more similarities than differences in patients with mild disease.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBrain
dc.subjectNeural Pathways
dc.subjectHumans
dc.subjectLewy Body Disease
dc.subjectAlzheimer Disease
dc.subjectMagnetic Resonance Imaging
dc.subjectBrain Mapping
dc.subjectRest
dc.subjectAged
dc.subjectFemale
dc.subjectMale
dc.titleFunctional connectivity in dementia with Lewy bodies: A within- and between-network analysis.
dc.typeArticle
prism.endingPage1129
prism.issueIdentifier3
prism.publicationDate2018
prism.publicationNameHum Brain Mapp
prism.startingPage1118
prism.volume39
dc.identifier.doi10.17863/CAM.32322
dcterms.dateAccepted2017-11-20
rioxxterms.versionofrecord10.1002/hbm.23901
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-03
dc.contributor.orcidSchumacher, Julia [0000-0001-7323-4789]
dc.contributor.orcidPeraza, Luis R [0000-0002-3419-0792]
dc.identifier.eissn1097-0193
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-11-29


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International