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dc.contributor.authorHoare, Matthew
dc.contributor.authorNarita, Masashi
dc.date.accessioned2018-11-13T00:30:34Z
dc.date.available2018-11-13T00:30:34Z
dc.date.issued2018
dc.identifier.isbn978-3-319-89511-6
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284955
dc.description.abstractCellular senescence, previously thought of as an autonomous tumour suppressor mechanism, is emerging as a phenotype and effector present throughout the life of an organism from embryogenesis to senile decline. Senescent cells have powerful non-autonomous effects upon multiple players within their microenvironment mainly through their secretory phenotype. How senescent cells co-ordinate numerous, sometimes functionally contrasting outputs through their secretome had previously been unclear. The Notch pathway, originally identified for its involvement in Drosophila wing development, has more recently been found to underpin diverse effects in human cancer. Here we discuss recent findings that suggest that Notch is intimately involved in the development of senescence and how it acts to co-ordinate the composition and functional effects of the senescence secretome. We also highlight the complex physical and functional interplay between Notch and p53, critical to both senescence and cancer. Understanding the interplay between Notch, p53 and senescence could allow us develop the therapeutics of the future for cancer and ageing.
dc.format.mediumPrint
dc.languageeng
dc.publisherSpringer International Publishing
dc.subjectImmune surveillance
dc.subjectInterleukins
dc.subjectNOTCH
dc.subjectRAS
dc.subjectSASP
dc.subjectSecretome
dc.subjectSenescence
dc.subjectTGF-beta
dc.subjectAging
dc.subjectAnimals
dc.subjectCellular Senescence
dc.subjectDrosophila Proteins
dc.subjectDrosophila melanogaster
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectReceptors, Notch
dc.subjectSignal Transduction
dc.subjectTumor Suppressor Protein p53
dc.titleNotch and Senescence.
dc.typeBook chapter
prism.endingPage318
prism.publicationDate2018
prism.startingPage299
prism.volume1066
dc.identifier.doi10.17863/CAM.32326
rioxxterms.versionofrecord10.1007/978-3-319-89512-3_15
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-01
dcterms.formatPrint
dc.contributor.orcidHoare, Matthew [0000-0001-5990-9604]
dc.contributor.orcidNarita, Masashi [0000-0001-7764-577X]
dcterms.isPartOfAdvances in Experimental Medicine and Biology
rioxxterms.typeBook chapter
pubs.funder-project-idCancer Research UK (19924)
pubs.funder-project-idMedical Research Council (MR/R010013/1)
pubs.funder-project-idCancer Research UK (CRUK-A19924)
cam.issuedOnline2018-07-19
rioxxterms.freetoread.startdate2019-01-31


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