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dc.contributor.authorRitchie, Karen
dc.contributor.authorCarrière, Isabelle
dc.contributor.authorHowett, David
dc.contributor.authorSu, Li
dc.contributor.authorHornberger, Michael
dc.contributor.authorO'Brien, John T
dc.contributor.authorRitchie, Craig W
dc.contributor.authorChan, Dennis
dc.date.accessioned2018-11-13T00:30:57Z
dc.date.available2018-11-13T00:30:57Z
dc.date.issued2018
dc.identifier.issn1387-2877
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/284969
dc.description.abstractImpairments in spatial processing due to hippocampal degeneration have been observed in the years immediately preceding the diagnosis of Alzheimer's disease (AD) dementia. The demonstration of changes in spatial processing in preceding decades would provide a cognitive marker for pre-clinical AD and an outcome measure for early intervention trials. The present study examined allocentric and egocentric spatial processing in relation to future dementia risk in a middle-aged cohort. The CAIDE Dementia Risk Score (DRS) was calculated for 188 persons aged 40 to 59, of whom 94 had a parent with dementia. Participants underwent the Four Mountains Test (4MT) of allocentric spatial processing, the Virtual Reality Supermarket Trolley Task (VRSTT) of egocentric spatial processing, and 3T MRI scans. A significant negative association was found between the DRS and 4MT (Spearman correlation - 0.26, p = 0.0006), but not with the VRSTT. The 4MT was also found to be a better predictor of risk than tests of episodic memory, verbal fluency, or executive functioning. The results suggest that allocentric rather than egocentric processing may be a potential indicator of risk for late-onset AD, consistent with the hypothesis that the earliest cognitive changes in AD are driven by tau-related degeneration in the medial temporal lobe rather than amyloid-only deposition in the medial parietal lobe.
dc.format.mediumPrint
dc.languageeng
dc.publisherIOS Press
dc.subjectBrain
dc.subjectHumans
dc.subjectAlzheimer Disease
dc.subjectGenetic Predisposition to Disease
dc.subjectRisk Factors
dc.subjectProspective Studies
dc.subjectCross-Sectional Studies
dc.subjectSelf Concept
dc.subjectParents
dc.subjectSpace Perception
dc.subjectNeuropsychological Tests
dc.subjectAge of Onset
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectSpatial Navigation
dc.titleAllocentric and Egocentric Spatial Processing in Middle-Aged Adults at High Risk of Late-Onset Alzheimer's Disease: The PREVENT Dementia Study.
dc.typeArticle
prism.endingPage896
prism.issueIdentifier3
prism.publicationDate2018
prism.publicationNameJ Alzheimers Dis
prism.startingPage885
prism.volume65
dc.identifier.doi10.17863/CAM.32340
dcterms.dateAccepted2018-07-10
rioxxterms.versionofrecord10.3233/JAD-180432
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-01
dc.contributor.orcidChan, Dennis [0000-0002-4265-3718]
dc.identifier.eissn1875-8908
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/M009041/1)
pubs.funder-project-idMedical Research Council (MR/M024873/1)


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