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dc.contributor.authorYoung, Matthew D
dc.contributor.authorMitchell, Thomas
dc.contributor.authorVieira Braga, Felipe A
dc.contributor.authorTran, Maxine GB
dc.contributor.authorStewart, Benjamin J
dc.contributor.authorFerdinand, John
dc.contributor.authorCollord, Grace
dc.contributor.authorBotting, Rachel A
dc.contributor.authorPopescu, Dorin-Mirel
dc.contributor.authorLoudon, Kevin W
dc.contributor.authorVento-Tormo, Roser
dc.contributor.authorStephenson, Emily
dc.contributor.authorCagan, Alex
dc.contributor.authorFarndon, Sarah J
dc.contributor.authorDel Castillo Velasco-Herrera, Martin
dc.contributor.authorGuzzo, Charlotte
dc.contributor.authorRichoz, Nathan
dc.contributor.authorMamanova, Lira
dc.contributor.authorAho, Tevita
dc.contributor.authorArmitage, James N
dc.contributor.authorRiddick, Antony CP
dc.contributor.authorMushtaq, Imran
dc.contributor.authorFarrell, Stephen
dc.contributor.authorRampling, Dyanne
dc.contributor.authorNicholson, James
dc.contributor.authorFilby, Andrew
dc.contributor.authorBurge, Johanna
dc.contributor.authorLisgo, Steven
dc.contributor.authorMaxwell, Patrick
dc.contributor.authorLindsay, Susan
dc.contributor.authorWarren, Anne
dc.contributor.authorStewart, Grant
dc.contributor.authorSebire, Neil
dc.contributor.authorColeman, Nicholas
dc.contributor.authorHaniffa, Muzlifah
dc.contributor.authorTeichmann, Sarah
dc.contributor.authorClatworthy, Menna
dc.contributor.authorBehjati, Sam
dc.date.accessioned2018-11-14T00:30:15Z
dc.date.available2018-11-14T00:30:15Z
dc.date.issued2018-08-10
dc.identifier.issn0036-8075
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285014
dc.description.abstractMessenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal tumors and normal tissue from fetal, pediatric, and adult kidneys. We matched childhood Wilms tumor with specific fetal cell types, thus providing evidence for the hypothesis that Wilms tumor cells are aberrant fetal cells. In adult renal cell carcinoma, we identified a canonical cancer transcriptome that matched a little-known subtype of proximal convoluted tubular cell. Analyses of the tumor composition defined cancer-associated normal cells and delineated a complex vascular endothelial growth factor (VEGF) signaling circuit. Our findings reveal the precise cellular identities and compositions of human kidney tumors.
dc.format.mediumPrint
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.subjectKidney
dc.subjectHumans
dc.subjectCarcinoma, Renal Cell
dc.subjectKidney Neoplasms
dc.subjectAdult
dc.subjectChild
dc.subjectWilms Tumor
dc.subjectGenetic Variation
dc.subjectSingle-Cell Analysis
dc.subjectTranscriptome
dc.titleSingle-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.
dc.typeArticle
prism.endingPage599
prism.issueIdentifier6402
prism.publicationDate2018
prism.publicationNameScience
prism.startingPage594
prism.volume361
dc.identifier.doi10.17863/CAM.32384
dcterms.dateAccepted2018-07-02
rioxxterms.versionofrecord10.1126/science.aat1699
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08
dc.contributor.orcidYoung, Matthew D [0000-0003-0937-5290]
dc.contributor.orcidMitchell, Thomas [0000-0003-0761-9503]
dc.contributor.orcidVieira Braga, Felipe A [0000-0003-0206-9258]
dc.contributor.orcidTran, Maxine GB [0000-0002-6034-4433]
dc.contributor.orcidStewart, Benjamin J [0000-0003-4522-0085]
dc.contributor.orcidFerdinand, John [0000-0003-0936-0128]
dc.contributor.orcidCollord, Grace [0000-0003-1924-4411]
dc.contributor.orcidStephenson, Emily [0000-0002-4244-4019]
dc.contributor.orcidFarndon, Sarah J [0000-0001-6024-4267]
dc.contributor.orcidDel Castillo Velasco-Herrera, Martin [0000-0001-5956-0211]
dc.contributor.orcidGuzzo, Charlotte [0000-0003-3742-5961]
dc.contributor.orcidMamanova, Lira [0000-0003-1463-8622]
dc.contributor.orcidLisgo, Steven [0000-0001-5186-3971]
dc.contributor.orcidMaxwell, Patrick [0000-0002-0338-2679]
dc.contributor.orcidLindsay, Susan [0000-0003-2980-4582]
dc.contributor.orcidWarren, Anne [0000-0002-1170-7867]
dc.contributor.orcidStewart, Grant [0000-0003-3188-9140]
dc.contributor.orcidColeman, Nicholas [0000-0002-5374-739X]
dc.contributor.orcidHaniffa, Muzlifah [0000-0002-3927-2084]
dc.contributor.orcidTeichmann, Sarah [0000-0002-6294-6366]
dc.contributor.orcidClatworthy, Menna [0000-0002-3340-9828]
dc.contributor.orcidBehjati, Sam [0000-0002-6600-7665]
dc.identifier.eissn1095-9203
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (096956/Z/11/Z)
pubs.funder-project-idMedical Research Council (MR/M008975/1)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0514-10122)
pubs.funder-project-idMedical Research Council (MR/K023934/1)
pubs.funder-project-idWellcome Trust (200110/Z/15/Z)
pubs.funder-project-idMedical Research Council (MR/N024907/1)
pubs.funder-project-idArthritis Research UK (21777)
rioxxterms.freetoread.startdate2019-08-31


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