Repository logo
 

Preparation of homoallylic amines via a three-component coupling process

Accepted version
Peer-reviewed

No Thumbnail Available

Type

Article

Change log

Authors

Ou, xiaoxu 
Battilocchio, claudio 
Ley, steven 

Abstract

A three-component synthesis of homoallylic amines is described. The allylboronic species were generated in situ by homologation of vinyl boroxines with trimethylsilyldiazomethane, then followed by trapping of the allylboron intermediate with imines. Twenty-seven compounds were successfully prepared in moderate to high yields. Imines bearing various functional groups were tolerated, including aliphatic, aromatic and heteroaromatic substituents. Further elaboration of some of the homoallylic amines to form azeditines is also reported.

Description

Keywords

0305 Organic Chemistry

Journal Title

Organic & Biomolecular Chemistry

Conference Name

Journal ISSN

1477-0539
1477-0539

Volume Title

16

Publisher

Royal Society of Chemistry (RSC)
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Syngenta Crop Protection EPSRC (EP/K009494/1, EP/M004120/1 and EP/K039520/1)
Relationships
Is supplemented by: