Identification of novel adenovirus genotype 90 in children from Bangladesh.
Houldcroft, Charlotte J
Beale, Mathew A
Sayeed, Md Abu
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Houldcroft, C. J., Beale, M. A., Sayeed, M. A., Qadri, F., Dougan, G., & Mutreja, A. (2018). Identification of novel adenovirus genotype 90 in children from Bangladesh.. Microb Genom, 4 (10) https://doi.org/10.1099/mgen.0.000221
Novel adenovirus genotypes are associated with outbreaks of disease, such as acute gastroenteritis, renal disease, upper respiratory tract infection and keratoconjunctivitis. Here, we identify novel and variant adenovirus genotypes in children coinfected with enterotoxigenic Escherichia coli, in Bangladesh. Metagenomic sequencing of stool was performed and whole adenovirus genomes were extracted. A novel species D virus, designated genotype 90 (P33H27F67) was identified, and the partial genome of a putative recombinant species B virus was recovered. Furthermore, the enteric types HAdV-A61 and HAdV-A40 were found in stool specimens. Knowledge of the diversity of adenovirus genomes circulating worldwide, especially in low-income countries where the burden of disease is high, will be required to ensure that future vaccination strategies cover the diversity of adenovirus strains associated with disease.
DNA virus, adenovirus, de novo assembly, diarrhoeal disease, metagenomics, whole-genome sequencing, Adenovirus Infections, Human, Adenoviruses, Human, Bangladesh, Child, Child, Preschool, Feces, Female, Gastroenteritis, Genome, Viral, Genotype, Humans, Keratoconjunctivitis, Male
This work was supported by NIHR Biomedical Research Centres in Cambridge (in particular the NIHR Cambridge BRC AMR Theme) and Wellcome Trust grant number 098051. This work was also supported by the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) which is grateful to the governments of Bangladesh, Canada, Sweden and the UK for providing core/unrestricted support. CJH is funded by the NIHR Cambridge Biomedical Research Centre (NHIR Cambridge, BRC) Antimicrobial Resistance theme. GD and MAB are supported by the Wellcome Trust. GD is supported by NIHR Cambridge, BRC. AM is funded by the DBT-Cambridge partnership.
Cambridge University Hospitals NHS Foundation Trust (CUH) (BRC)
External DOI: https://doi.org/10.1099/mgen.0.000221
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285065
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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