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dc.contributor.authorHouldcroft, Charlotte J
dc.contributor.authorBeale, Mathew A
dc.contributor.authorSayeed, Md Abu
dc.contributor.authorQadri, Firdausi
dc.contributor.authorDougan, Gordon
dc.contributor.authorMutreja, Ankur
dc.date.accessioned2018-11-14T00:31:51Z
dc.date.available2018-11-14T00:31:51Z
dc.date.issued2018-10
dc.identifier.issn2057-5858
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285065
dc.description.abstractNovel adenovirus genotypes are associated with outbreaks of disease, such as acute gastroenteritis, renal disease, upper respiratory tract infection and keratoconjunctivitis. Here, we identify novel and variant adenovirus genotypes in children coinfected with enterotoxigenic Escherichia coli, in Bangladesh. Metagenomic sequencing of stool was performed and whole adenovirus genomes were extracted. A novel species D virus, designated genotype 90 (P33H27F67) was identified, and the partial genome of a putative recombinant species B virus was recovered. Furthermore, the enteric types HAdV-A61 and HAdV-A40 were found in stool specimens. Knowledge of the diversity of adenovirus genomes circulating worldwide, especially in low-income countries where the burden of disease is high, will be required to ensure that future vaccination strategies cover the diversity of adenovirus strains associated with disease.
dc.description.sponsorshipThis work was supported by NIHR Biomedical Research Centres in Cambridge (in particular the NIHR Cambridge BRC AMR Theme) and Wellcome Trust grant number 098051. This work was also supported by the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) which is grateful to the governments of Bangladesh, Canada, Sweden and the UK for providing core/unrestricted support. CJH is funded by the NIHR Cambridge Biomedical Research Centre (NHIR Cambridge, BRC) Antimicrobial Resistance theme. GD and MAB are supported by the Wellcome Trust. GD is supported by NIHR Cambridge, BRC. AM is funded by the DBT-Cambridge partnership.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherMicrobiology Society
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectFeces
dc.subjectHumans
dc.subjectAdenoviruses, Human
dc.subjectAdenovirus Infections, Human
dc.subjectGastroenteritis
dc.subjectKeratoconjunctivitis
dc.subjectGenotype
dc.subjectGenome, Viral
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectBangladesh
dc.subjectFemale
dc.subjectMale
dc.titleIdentification of novel adenovirus genotype 90 in children from Bangladesh.
dc.typeArticle
prism.issueIdentifier10
prism.publicationDate2018
prism.publicationNameMicrob Genom
prism.volume4
dc.identifier.doi10.17863/CAM.32435
dcterms.dateAccepted2018-08-30
rioxxterms.versionofrecord10.1099/mgen.0.000221
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-10
dc.contributor.orcidHouldcroft, Charlotte [0000-0002-1833-5285]
dc.contributor.orcidDougan, Gordon [0000-0003-0022-965X]
dc.contributor.orcidMutreja, Ankur [0000-0002-1118-8075]
dc.identifier.eissn2057-5858
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (BRC)
cam.issuedOnline2018-09-24


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International