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dc.contributor.authorWang, Zhengming
dc.contributor.authorHardcastle, Thomas
dc.contributor.authorCanto Pastor, Alex
dc.contributor.authorYip, Wing Hin
dc.contributor.authorTang, Shuoya
dc.contributor.authorBaulcombe, David
dc.date.accessioned2018-11-14T00:32:29Z
dc.date.available2018-11-14T00:32:29Z
dc.date.issued2018-09-01
dc.identifier.issn0890-9369
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285087
dc.description.abstractTomato Dicer-like2 (slDCL2) is a key component of resistance pathways against potato virus X (PVX) and tobacco mosaic virus (TMV). It is also required for production of endogenous small RNAs, including miR6026 and other noncanonical microRNAs (miRNAs). The slDCL2 mRNAs are targets of these slDCL2-dependent RNAs in a feedback loop that was disrupted by target mimic RNAs of miR6026. In lines expressing these RNAs, there was correspondingly enhanced resistance against PVX and TMV. These findings illustrate a novel miRNA pathway in plants and a crop protection strategy in which miRNA target mimicry elevates expression of defense-related mRNAs.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherCold Spring Harbor Laboratory
dc.subjectRNA Viruses
dc.subjectLycopersicon esculentum
dc.subjectDisease Susceptibility
dc.subjectRibonuclease III
dc.subjectMicroRNAs
dc.subjectPlant Diseases
dc.subjectMutation
dc.subjectRNA, Small Untranslated
dc.subjectCRISPR-Cas Systems
dc.titleA novel DCL2-dependent miRNA pathway in tomato affects susceptibility to RNA viruses.
dc.typeArticle
prism.endingPage1160
prism.issueIdentifier17-18
prism.publicationDate2018
prism.publicationNameGenes Dev
prism.startingPage1155
prism.volume32
dc.identifier.doi10.17863/CAM.32457
dcterms.dateAccepted2018-06-27
rioxxterms.versionofrecord10.1101/gad.313601.118
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-09
dc.contributor.orcidHardcastle, Thomas [0000-0002-9328-5011]
dc.contributor.orcidBaulcombe, David [0000-0003-0780-6878]
dc.identifier.eissn1549-5477
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Research Council (340642)
pubs.funder-project-idInternational Balzan Prize Foundation (10957)
pubs.funder-project-idRoyal Society (RP170001)
pubs.funder-project-idRoyal Society (RP/EA/180018)
cam.issuedOnline2018-08-27
rioxxterms.freetoread.startdate2019-09-30


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