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dc.contributor.authorMattle-Greminger, Maja P
dc.contributor.authorBilgin Sonay, Tugce
dc.contributor.authorNater, Alexander
dc.contributor.authorPybus, Marc
dc.contributor.authorDesai, Tariq
dc.contributor.authorde Valles, Guillem
dc.contributor.authorCasals, Ferran
dc.contributor.authorScally, Aylwyn
dc.contributor.authorBertranpetit, Jaume
dc.contributor.authorMarques-Bonet, Tomas
dc.contributor.authorvan Schaik, Carel P
dc.contributor.authorAnisimova, Maria
dc.contributor.authorKrützen, Michael
dc.date.accessioned2018-11-15T07:42:42Z
dc.date.available2018-11-15T07:42:42Z
dc.date.issued2018-11-15
dc.identifier.citationGenome Biology. 2018 Nov 15;19(1):193
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285094
dc.description.abstractAbstract Background Integrating demography and adaptive evolution is pivotal to understanding the evolutionary history and conservation of great apes. However, little is known about the adaptive evolution of our closest relatives, in particular if and to what extent adaptions to environmental differences have occurred. Here, we used whole-genome sequencing data from critically endangered orangutans from North Sumatra (Pongo abelii) and Borneo (P. pygmaeus) to investigate adaptive responses of each species to environmental differences during the Pleistocene. Results Taking into account the markedly disparate demographic histories of each species after their split ~ 1 Ma ago, we show that persistent environmental differences on each island had a strong impact on the adaptive evolution of the genus Pongo. Across a range of tests for positive selection, we find a consistent pattern of between-island and species differences. In the more productive Sumatran environment, the most notable signals of positive selection involve genes linked to brain and neuronal development, learning, and glucose metabolism. On Borneo, however, positive selection comprised genes involved in lipid metabolism, as well as cardiac and muscle activities. Conclusions We find strikingly different sets of genes appearing to have evolved under strong positive selection in each species. In Sumatran orangutans, selection patterns were congruent with well-documented cognitive and behavioral differences between the species, such as a larger and more complex cultural repertoire and higher degrees of sociality. However, in Bornean orangutans, selective responses to fluctuating environmental conditions appear to have produced physiological adaptations to generally lower and temporally more unpredictable food supplies.
dc.titleGenomes reveal marked differences in the adaptive evolution between orangutan species
dc.typeJournal Article
dc.date.updated2018-11-15T07:42:40Z
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.identifier.doi10.17863/CAM.32465
rioxxterms.versionofrecord10.1186/s13059-018-1562-6


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