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dc.contributor.authorJonker, Tanya R
dc.contributor.authorDimsdale-Zucker, Halle
dc.contributor.authorRitchey, Maureen
dc.contributor.authorClarke, Alex
dc.contributor.authorRanganath, Charan
dc.date.accessioned2018-11-16T00:31:06Z
dc.date.available2018-11-16T00:31:06Z
dc.date.issued2018-10-23
dc.identifier.issn0027-8424
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285143
dc.description.abstractRemembering is a complex process that involves recalling specific details, such as who you were with when you celebrated your last birthday, as well as contextual information, such as the place where you celebrated. It is well established that the act of remembering enhances long-term retention of the retrieved information, but the neural and cognitive mechanisms that drive memory enhancement are not yet understood. One possibility is that the process of remembering results in reactivation of the broader episodic context. Consistent with this idea, in two experiments, we found that multiple retrieval attempts enhanced long-term retention of both the retrieved object and the nontarget object that shared scene context, compared with a restudy control. Using representational similarity analysis of fMRI data in experiment 2, we found that retrieval resulted in greater neural reactivation of both the target objects and contextually linked objects compared with restudy. Furthermore, this reactivation occurred in a network of medial and lateral parietal lobe regions that have been linked to episodic recollection. The results demonstrate that retrieving a memory can enhance retention of information that is linked in the broader event context and the hippocampus and a posterior medial network of parietal cortical areas (also known as the Default Network) play complementary roles in supporting the reactivation of episodically linked information during retrieval.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherProceedings of the National Academy of Sciences
dc.subjectHippocampus
dc.subjectParietal Lobe
dc.subjectTemporal Lobe
dc.subjectNerve Net
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectBrain Mapping
dc.subjectMental Recall
dc.subjectReaction Time
dc.subjectImage Processing, Computer-Assisted
dc.subjectFemale
dc.subjectMale
dc.subjectMemory, Episodic
dc.titleNeural reactivation in parietal cortex enhances memory for episodically linked information.
dc.typeArticle
prism.endingPage11089
prism.issueIdentifier43
prism.publicationDate2018
prism.publicationNameProc Natl Acad Sci U S A
prism.startingPage11084
prism.volume115
dc.identifier.doi10.17863/CAM.32514
dcterms.dateAccepted2018-08-14
rioxxterms.versionofrecord10.1073/pnas.1800006115
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-10-08
dc.contributor.orcidClarke, Alex [0000-0001-7768-5229]
dc.identifier.eissn1091-6490
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-10-08
rioxxterms.freetoread.startdate2019-10-08


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