Show simple item record

dc.contributor.authorGruel, Jeremy
dc.contributor.authorDeichmann, Julia
dc.contributor.authorLandrein, Benoit
dc.contributor.authorHitchcock, Thomas
dc.contributor.authorJonsson, Henrik
dc.date.accessioned2018-11-16T00:31:16Z
dc.date.available2018-11-16T00:31:16Z
dc.date.issued2018
dc.identifier.issn2056-7189
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285149
dc.description.abstractThe plant shoot apical meristem holds a stem cell niche from which all aerial organs originate. Using a computational approach we show that a mixture of monomers and heterodimers of the transcription factors WUSCHEL and HAIRY MERISTEM is sufficient to pattern the stem cell niche, and predict that immobile heterodimers form a regulatory "pocket" surrounding the stem cells. The model achieves to reproduce an array of perturbations, including mutants and tissue size modifications. We also show its ability to reproduce the recently observed dynamical shift of the stem cell niche during the development of an axillary meristem. The work integrates recent experimental results to answer the longstanding question of how the asymmetry of expression between the stem cell marker CLAVATA3 and its activator WUSCHEL is achieved, and recent findings of plasticity in the system.
dc.description.sponsorshipGatsby Charitable Foundation (GAT3395-PR4)
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe interaction of transcription factors controls the spatial layout of plant aerial stem cell niches.
dc.typeArticle
prism.publicationDate2018
prism.publicationNameNPJ Syst Biol Appl
prism.startingPage36
prism.volume4
dc.identifier.doi10.17863/CAM.32519
dcterms.dateAccepted2018-07-31
rioxxterms.versionofrecord10.1038/s41540-018-0072-1
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-01
dc.contributor.orcidLandrein, Benoit [0000-0002-2371-9996]
dc.contributor.orcidJonsson, Henrik [0000-0003-2340-588X]
dc.identifier.eissn2056-7189
rioxxterms.typeJournal Article/Review
pubs.funder-project-idGatsby Charitable Foundation (unknown)
pubs.funder-project-idGatsby Charitable Foundation (GAT3395/PR4)
cam.issuedOnline2018-09-06


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International