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dc.contributor.authorHailwood, Jonathan M
dc.contributor.authorGilmour, Gary
dc.contributor.authorRobbins, Trevor W
dc.contributor.authorSaksida, Lisa M
dc.contributor.authorBussey, Timothy J
dc.contributor.authorMarston, Hugh M
dc.contributor.authorGastambide, Francois
dc.date.accessioned2018-11-17T00:30:42Z
dc.date.available2018-11-17T00:30:42Z
dc.date.issued2018-11
dc.identifier.issn0953-816X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285341
dc.description.abstractGoal-directed motivated behaviour is crucial for everyday life. Such behaviour is often measured, in rodents, under a progressive ratio (PR) schedule of reinforcement. Previous studies have identified a few brain structures critical for supporting PR performance. However, the association between neural activity within these regions and individual differences in effort-related behaviour is not known. Presently, we used constant potential in vivo oxygen amperometry, a surrogate for functional resonance imaging in rodents, to assess changes in tissue oxygen levels within the nucleus accumbens (NAc) and orbitofrontal cortex (OFC) in male Wistar rats performing a PR task. Within both regions, oxygen responses to rewards increased as the effort exerted to obtain the rewards was larger. Furthermore, higher individual breakpoints were associated with greater magnitude NAc oxygen responses. This association could not be explained by temporal confounds and remained significant when controlling for the different number of completed trials. Animals with higher breakpoints also showed greater magnitude NAc oxygen responses to rewards delivered independently of any behaviour. In contrast, OFC oxygen responses were not associated with individual differences in behavioural performance. The present results suggest that greater NAc oxygen responses following rewards, through a process of incentive motivation, may allow organisms to remain on task for longer and to overcome greater effort costs.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNucleus Accumbens
dc.subjectAnimals
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectOxygen
dc.subjectElectrodes, Implanted
dc.subjectMotivation
dc.subjectReinforcement Schedule
dc.subjectReward
dc.subjectOxygen Consumption
dc.subjectMale
dc.subjectPhysical Exertion
dc.titleOxygen responses within the nucleus accumbens are associated with individual differences in effort exertion in rats.
dc.typeArticle
prism.endingPage2987
prism.issueIdentifier9
prism.publicationDate2018
prism.publicationNameEur J Neurosci
prism.startingPage2971
prism.volume48
dc.identifier.doi10.17863/CAM.32710
dcterms.dateAccepted2018-09-10
rioxxterms.versionofrecord10.1111/ejn.14150
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-11
dc.contributor.orcidHailwood, Jonathan M [0000-0002-5835-2143]
dc.identifier.eissn1460-9568
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (1505392)
cam.issuedOnline2018-09-28


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International