Show simple item record

dc.contributor.authorRanmuthu, Chanuka DSen
dc.contributor.authorRanmuthu, Charindu KIen
dc.contributor.authorKhan, Wasimen
dc.date.accessioned2018-11-17T00:31:20Z
dc.date.available2018-11-17T00:31:20Z
dc.date.issued2018-09-10en
dc.identifier.issn1523-3774
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285363
dc.description.abstractPurpose of Review: Recent studies have investigated the effect of treatments containing adipose-derived mesenchymal stem cells (ADMSCs) on human osteoarthritis. These have mostly used biologic adjuvants which may influence results. Thus, the purpose of this systematic review is to evaluate the current literature on these treatments when used in isolation. Recent findings: 5 studies in this review used cultured ADMSCs, whilst 4 studies used stromal vascular fraction and 3 used micro-fragmented adipose tissue to deliver ADMSCs. No studies reported serious treatment-related adverse effects and all reported improvements in clinical measures for at least one dose. This was not necessarily reflected in imaging evaluations nor were improvements always maintained. Summary: Current low-level evidence is limited due to variability in study methodology but indicates that treatments containing ADMSCs, when used in isolation, are safe and have the potential to reduce pain and improve function. Randomized controlled trials are now needed.
dc.format.mediumElectronicen
dc.languageengen
dc.publisherSpringer Nature
dc.subjectMesenchymal Stem Cellsen
dc.subjectHumansen
dc.subjectOsteoarthritisen
dc.subjectTreatment Outcomeen
dc.subjectMesenchymal Stem Cell Transplantationen
dc.subjectInjections, Intra-Articularen
dc.subjectEvidence-Based Medicineen
dc.titleEvaluating the Current Literature on Treatments Containing Adipose-Derived Stem Cells for Osteoarthritis: a Progress Update.en
dc.typeArticle
prism.issueIdentifier11en
prism.publicationDate2018en
prism.publicationNameCurrent rheumatology reportsen
prism.startingPage67
prism.volume20en
dc.identifier.doi10.17863/CAM.32730
dcterms.dateAccepted2018-08-22en
rioxxterms.versionofrecord10.1007/s11926-018-0776-7en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-09-10en
dc.contributor.orcidKhan, Wasim [0000-0003-3106-5424]
dc.identifier.eissn1534-6307
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_PC_12009)
rioxxterms.freetoread.startdate2019-09-10


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record