Multivalent Crown Ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe4 L6 Tetrahedron.
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Authors
Publication Date
2018-10-22Journal Title
Angew Chem Int Ed Engl
ISSN
1433-7851
Publisher
Wiley
Volume
57
Issue
43
Pages
14121-14124
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
von Krbek, L. K., Roberts, D. A., Pilgrim, B. S., Schalley, C. A., & Nitschke, J. R. (2018). Multivalent Crown Ether Receptors Enable Allosteric Regulation of Anion Exchange in an Fe4 L6 Tetrahedron.. Angew Chem Int Ed Engl, 57 (43), 14121-14124. https://doi.org/10.1002/anie.201808534
Abstract
We report a strategy for regulating the rate of internally bound anion exchange within an Fe4 L6 metal-organic tetrahedron through external coordination of tripodal tris(alkylammonium) cations. The cage features three flexible 18-crown-6 receptors at each of its FeII vertices, facilitating strong tritopic interactions with tris(ammonium) cations to "cap" the vertices of the tetrahedron. This capping mechanism restricts the flexibility of the cage framework, thereby reducing the rate of anion exchange within its central cavity by 20-fold. Thus, we demonstrate the first use of an externally bound multivalent effector to allosterically control internal guest binding in a molecular cage.
Sponsorship
UK Engineering and Physical Sciences Research Council (EPSRC EP/P027067/1), the European Research Council (695009), and the Deutsche Forschungsgemeinschaft (SFB 765)
Funder references
Royal Commission for the Exhibition of 1851 (RF478/2016)
Engineering and Physical Sciences Research Council (EP/P027067/1)
European Research Council (695009)
Identifiers
External DOI: https://doi.org/10.1002/anie.201808534
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285366
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