Cellular switches orchestrate rhythmic circuits.
Springer Science and Business Media LLC
MetadataShow full item record
Drion, G., Franci, A., & Sepulchre, R. (2019). Cellular switches orchestrate rhythmic circuits.. Biol Cybern, 113 (1-2), 71-82. https://doi.org/10.1007/s00422-018-0778-6
Small inhibitory neuronal circuits have long been identified as key neuronal motifs to generate and modulate the coexisting rhythms of various motor functions. Our paper highlights the role of a cellular switching mechanism to orchestrate such circuits. The cellular switch makes the circuits reconfigurable, robust, adaptable, and externally controllable. Without this cellular mechanism, the circuit rhythms entirely rely on specific tunings of the synaptic connectivity, which makes them rigid, fragile, and difficult to control externally. We illustrate those properties on the much studied architecture of a small network controlling both the pyloric and gastric rhythms of crabs. The cellular switch is provided by a slow negative conductance often neglected in mathematical modeling of central pattern generators. We propose that this conductance is simple to model and key to computational studies of rhythmic circuit neuromodulation.
Central pattern generators, Mathematical modeling, Neuromodulation, Action Potentials, Animals, Brachyura, Computer Simulation, Models, Neurological, Nerve Net, Neurons, Nonlinear Dynamics, Periodicity
European Research Council (670645)
External DOI: https://doi.org/10.1007/s00422-018-0778-6
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285374
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: email@example.com