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dc.contributor.authorSharp, Stephen
dc.contributor.authorWestgate, Kate
dc.contributor.authorBrage, Soren
dc.contributor.authorWareham, Nicholas
dc.date.accessioned2018-11-17T00:32:06Z
dc.date.available2018-11-17T00:32:06Z
dc.date.issued2018-09-10
dc.identifier.issn1472-6823
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285393
dc.description.abstractBackground Type 2 diabetes is a serious clinical problem in both India and the UK. Adoption of a healthy lifestyle through dietary and physical activity modification can help prevent type 2 diabetes. However, implementing lifestyle modification programmes to high risk groups is expensive and alternative cheaper methods are needed. We are using a short messaging service (SMS) programme in our study as a tool to provide healthy lifestyle advice and an aid to motivation. The aim of the study is to assess the efficacy and user acceptability of text messaging employed in this way for people with pre-diabetes (HbA1c 6.0% to ≤6.4%; 42–47 mmol/mol) in the UK and India. Methods/design This is a randomised, controlled trial with participants followed up for 2 years. After being screened and receiving a structured education programme for prediabetes, participants are randomised to a control or intervention group. In the intervention group, text messages are delivered 2–3 times weekly and contain educational, motivational and supportive content on diet, physical activity, lifestyle and smoking. The control group undergoes monitoring only. In India, the trial involves 5 visits after screening (0, 6, 12, 18 and 24 months). In the UK there are 4 visits after screening (0, 6, 12 and 24 months). Questionnaires (EQ-5D, RPAQ, Transtheoretical Model of Behavioural Change, and food frequency (UK)/24 h dietary recall (India)) and physical activity monitors (Actigraph GT3X+ accelerometers) are assessed at baseline and all follow-up visits. The SMS acceptability questionnaires are evaluated in all follow-up visits. The primary outcome is progression to type 2 diabetes as defined by an HbA1c of 6.5% or over(India) and by any WHO criterion(UK). Secondary outcomes are the changes in body weight, body mass index, waist circumference, blood pressure, fasting plasma glucose; lipids; proportion of participants achieving HbA1c ≤6.0%; HOMA-IR; HOMA-β; acceptability of SMS; dietary parameters; physical activity and quality of life. Discussion The study is designed to assess the efficacy of tailored text messaging in addition to standard lifestyle advice to reduce the progression from prediabetes to type 2 diabetes in the two different countries.
dc.description.sponsorshipFunding was obtained jointly from the Indian Council for Medical Research and the UK Medical Research Council (Joint funding ref.: MR/J000183/1).
dc.publisherBioMed Central
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleProtocol for a clinical trial of text messaging in addition to standard care versus standard care alone in prevention of type 2 diabetes through lifestyle modification in India and the UK
dc.typeArticle
prism.number63
prism.publicationNameBMC Endocrine Disorders
prism.volume18
dc.identifier.doi10.17863/CAM.32759
dcterms.dateAccepted2018-08-31
rioxxterms.versionofrecord10.1186/s12902-018-0293-8
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2018-08-31
dc.contributor.orcidSharp, Stephen [0000-0003-2375-1440]
dc.contributor.orcidWestgate, Kate [0000-0002-0283-3562]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.identifier.eissn1472-6823
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/J000183/1)
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idMedical Research Council (MC_UU_12015/3)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
cam.issuedOnline2018-09-10


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International