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dc.contributor.authorGapp, K
dc.contributor.authorvan Steenwyk, G
dc.contributor.authorGermain, PL
dc.contributor.authorMatsushima, Wayo
dc.contributor.authorRudolph, Konrad
dc.contributor.authorManuella, F
dc.contributor.authorRoszkowski, M
dc.contributor.authorVernaz, Grégoire
dc.contributor.authorGhosh, T
dc.contributor.authorPelczar, P
dc.contributor.authorMansuy, IM
dc.contributor.authorMiska, Eric
dc.date.accessioned2018-11-19T00:30:10Z
dc.date.available2018-11-19T00:30:10Z
dc.date.issued2020-09
dc.identifier.issn1359-4184
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285401
dc.description.abstractPsychiatric diseases have a strong heritable component known to not be restricted to DNA sequence-based genetic inheritance alone but to also involve epigenetic factors in germ cells. Initial evidence suggested that sperm RNA is causally linked to the transmission of symptoms induced by traumatic experiences. Here, we show that alterations in long RNA in sperm contribute to the inheritance of specific trauma symptoms. Injection of long RNA fraction from sperm of males exposed to postnatal trauma recapitulates the effects on food intake, glucose response to insulin and risk-taking in adulthood whereas the small RNA fraction alters body weight and behavioural despair. Alterations in long RNA are maintained after fertilization, suggesting a direct link between sperm and embryo RNA.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectSpermatozoa
dc.subjectRNA
dc.subjectDNA Methylation
dc.subjectEpigenesis, Genetic
dc.subjectMale
dc.subjectEpigenomics
dc.titleAlterations in sperm long RNA contribute to the epigenetic inheritance of the effects of postnatal trauma.
dc.typeArticle
prism.endingPage2174
prism.issueIdentifier9
prism.publicationDate2020
prism.publicationNameMol Psychiatry
prism.startingPage2162
prism.volume25
dc.identifier.doi10.17863/CAM.32768
dcterms.dateAccepted2018-09-11
rioxxterms.versionofrecord10.1038/s41380-018-0271-6
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-09
dc.contributor.orcidGermain, PL [0000-0003-3418-4218]
dc.contributor.orcidMatsushima, Wayo [0000-0002-0334-2423]
dc.contributor.orcidRudolph, Konrad [0000-0002-9866-7051]
dc.contributor.orcidVernaz, Grégoire [0000-0001-8942-2370]
dc.contributor.orcidMansuy, IM [0000-0001-7785-5371]
dc.contributor.orcidMiska, Eric [0000-0002-4450-576X]
dc.identifier.eissn1476-5578
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Research Council (260688)
pubs.funder-project-idWellcome Trust (104640/Z/14/Z)
pubs.funder-project-idCancer Research UK (18583)
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idCancer Research UK (C6946/A24843)
pubs.funder-project-idWellcome Trust (203144/Z/16/Z)
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)
cam.issuedOnline2018-10-30
cam.orpheus.successThu Jan 30 10:54:12 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International