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dc.contributor.authorBradbury, Kathryn E
dc.contributor.authorAppleby, Paul N
dc.contributor.authorTipper, Sarah J
dc.contributor.authorTravis, Ruth C
dc.contributor.authorAllen, Naomi E
dc.contributor.authorKvaskoff, Marina
dc.contributor.authorOvervad, Kim
dc.contributor.authorTjønneland, Anne
dc.contributor.authorHalkjaer, Jytte
dc.contributor.authorCervenka, Iris
dc.contributor.authorMahamat-Saleh, Yahya
dc.contributor.authorBonnet, Fabrice
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorFortner, Renée T
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLa Vecchia, Carlo
dc.contributor.authorStratigos, Alexander J
dc.contributor.authorPalli, Domenico
dc.contributor.authorGrioni, Sara
dc.contributor.authorMatullo, Giuseppe
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorPeeters, Petra H
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorGhiasvand, Reza
dc.contributor.authorVeierød, Marit B
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorBonet, Catalina
dc.contributor.authorMolina, Elena
dc.contributor.authorHuerta, José M
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorMerino, Susana
dc.contributor.authorIsaksson, Karolin
dc.contributor.authorStocks, Tanja
dc.contributor.authorLjuslinder, Ingrid
dc.contributor.authorHemmingsson, Oskar
dc.contributor.authorWareham, Nicholas
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorGunter, Marc J
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorTsilidis, Konstantinos K
dc.contributor.authorAune, Dagfinn
dc.contributor.authorRiboli, Elio
dc.contributor.authorKey, Timothy J
dc.date.accessioned2018-11-21T00:30:27Z
dc.date.available2018-11-21T00:30:27Z
dc.date.issued2019-03-01
dc.identifier.issn0020-7136
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285504
dc.description.abstractInsulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case-control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.subjectHumans
dc.subjectMelanoma
dc.subjectBreast Neoplasms
dc.subjectProstatic Neoplasms
dc.subjectInsulin-Like Growth Factor I
dc.subjectOdds Ratio
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectProspective Studies
dc.subjectNutritional Status
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectEurope
dc.subjectFemale
dc.subjectMale
dc.titleCirculating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition.
dc.typeArticle
prism.endingPage966
prism.issueIdentifier5
prism.publicationDate2019
prism.publicationNameInt J Cancer
prism.startingPage957
prism.volume144
dc.identifier.doi10.17863/CAM.32862
dcterms.dateAccepted2018-07-25
rioxxterms.versionofrecord10.1002/ijc.31854
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-03
dc.contributor.orcidBradbury, Kathryn E [0000-0003-3345-7333]
dc.contributor.orcidKvaskoff, Marina [0000-0002-4557-3772]
dc.contributor.orcidLa Vecchia, Carlo [0000-0003-1441-897X]
dc.contributor.orcidPalli, Domenico [0000-0002-5558-2437]
dc.contributor.orcidMatullo, Giuseppe [0000-0003-0674-7757]
dc.contributor.orcidVeierød, Marit B [0000-0002-2083-2758]
dc.contributor.orcidLjuslinder, Ingrid [0000-0002-5046-1820]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidRinaldi, Sabina [0000-0002-6846-1204]
dc.identifier.eissn1097-0215
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idMedical Research Council (G0401527)
pubs.funder-project-idMedical Research Council (G1000143)
pubs.funder-project-idMedical Research Council (MR/N003284/1)
cam.issuedOnline2018-12-07
rioxxterms.freetoread.startdate2019-09-07


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