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dc.contributor.authorStepien, Magdalena
dc.contributor.authorJenab, Mazda
dc.contributor.authorFreisling, Heinz
dc.contributor.authorBecker, Niels-Peter
dc.contributor.authorCzuban, Magdalena
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOlsen, Anja
dc.contributor.authorOvervad, Kim
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorMancini, Francesca Romana
dc.contributor.authorSavoye, Isabelle
dc.contributor.authorKatzke, Verena
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorIqbal, Khalid
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorBamia, Christina
dc.contributor.authorOrfanos, Philippos
dc.contributor.authorPalli, Domenico
dc.contributor.authorSieri, Sabina
dc.contributor.authorTumino, Rosario
dc.contributor.authorNaccarati, Alessio
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBueno-de-Mesquita, HB As
dc.contributor.authorPeeters, Petra H
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorMerino, Susana
dc.contributor.authorJakszyn, Paula
dc.contributor.authorSanchez, Maria-Jose
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorHuerta, José María
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorBoden, Stina
dc.contributor.authorvan Guelpen, Behany
dc.contributor.authorWareham, Nick
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorBradbury, Kathryn E
dc.contributor.authorCross, Amanda J
dc.contributor.authorSchomburg, Lutz
dc.contributor.authorHughes, David J
dc.date.accessioned2018-11-21T00:31:21Z
dc.date.available2018-11-21T00:31:21Z
dc.date.issued2017-07-01
dc.identifier.issn0143-3334
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285537
dc.description.abstractAdequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to investigate the association between circulating levels of copper and zinc, and their calculated ratio, with risk of CRC development. Copper and zinc levels were measured by reflection X-ray fluorescence spectrometer in 966 cases and 966 matched controls. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression and are presented for the fifth versus first quintile. Higher circulating concentration of copper was associated with a raised CRC risk (OR = 1.50; 95% CI: 1.06, 2.13; P-trend = 0.02) whereas an inverse association with cancer risk was observed for higher zinc levels (OR = 0.65; 95% CI: 0.43, 0.97; P-trend = 0.07). Consequently, the ratio of copper/zinc was positively associated with CRC (OR = 1.70; 95% CI: 1.20, 2.40; P-trend = 0.0005). In subgroup analyses by follow-up time, the associations remained statistically significant only in those diagnosed within 2 years of blood collection. In conclusion, these data suggest that copper or copper levels in relation to zinc (copper to zinc ratio) become imbalanced in the process of CRC development. Mechanistic studies into the underlying mechanisms of regulation and action are required to further examine a possible role for higher copper and copper/zinc ratio levels in CRC development and progression.
dc.format.mediumPrint
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.subjectHumans
dc.subjectColorectal Neoplasms
dc.subjectCopper
dc.subjectZinc
dc.subjectRisk Factors
dc.subjectCase-Control Studies
dc.subjectProspective Studies
dc.subjectOxidative Stress
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectMale
dc.subjectBiomarkers, Tumor
dc.titlePre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
dc.typeArticle
prism.endingPage707
prism.issueIdentifier7
prism.publicationDate2017
prism.publicationNameCarcinogenesis
prism.startingPage699
prism.volume38
dc.identifier.doi10.17863/CAM.32894
dcterms.dateAccepted2017-05-30
rioxxterms.versionofrecord10.1093/carcin/bgx051
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-07
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidKhaw, Kay-Tee [0000-0002-8802-2903]
dc.identifier.eissn1460-2180
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (G1000143)
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idMedical Research Council (G0401527)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0512-10135)
pubs.funder-project-idMedical Research Council (MR/N003284/1)
cam.issuedOnline2017-06-01
rioxxterms.freetoread.startdate2018-07-31


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