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dc.contributor.authorGolan, Karin
dc.contributor.authorKumari, Anju
dc.contributor.authorKollet, Orit
dc.contributor.authorKhatib-Massalha, Eman
dc.contributor.authorSubramaniam, Mohana Devi
dc.contributor.authorFerreira, Zulma S
dc.contributor.authorAvemaria, Francesca
dc.contributor.authorRzeszotek, Sylwia
dc.contributor.authorGarcía-García, Andrés
dc.contributor.authorXie, Stephanie
dc.contributor.authorFlores-Figueroa, Eugenia
dc.contributor.authorGur-Cohen, Shiri
dc.contributor.authorItkin, Tomer
dc.contributor.authorLudin-Tal, Aya
dc.contributor.authorMassalha, Hassan
dc.contributor.authorBernshtein, Biana
dc.contributor.authorCiechanowicz, Andrzej K
dc.contributor.authorBrandis, Alexander
dc.contributor.authorMehlman, Tevie
dc.contributor.authorBhattacharya, Suditi
dc.contributor.authorBertagna, Mayla
dc.contributor.authorCheng, Hui
dc.contributor.authorPetrovich-Kopitman, Ekaterina
dc.contributor.authorJanus, Tomasz
dc.contributor.authorKaushansky, Nathali
dc.contributor.authorCheng, Tao
dc.contributor.authorSagi, Irit
dc.contributor.authorRatajczak, Mariusz Z
dc.contributor.authorMéndez-Ferrer, Simón
dc.contributor.authorDick, John E
dc.contributor.authorMarkus, Regina P
dc.contributor.authorLapidot, Tsvee
dc.date.accessioned2018-11-21T00:31:32Z
dc.date.available2018-11-21T00:31:32Z
dc.date.issued2018-10-04
dc.identifier.issn1934-5909
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285544
dc.description.abstractHematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating hematopoietic stem cells (LT-HSCs), with intensive daily production of mature leukocytes and blood replenishment. We found two daily peaks of BM HSPC activity that are initiated by onset of light and darkness providing this coupling. Both peaks follow transient elevation of BM norepinephrine and TNF secretion, which temporarily increase HSPC reactive oxygen species (ROS) levels. Light-induced norepinephrine and TNF secretion augments HSPC differentiation and increases vascular permeability to replenish the blood. In contrast, darkness-induced TNF increases melatonin secretion to drive renewal of HSPCs and LT-HSC potential through modulating surface CD150 and c-Kit expression, increasing COX-2/αSMA+ macrophages, diminishing vascular permeability, and reducing HSPC ROS levels. These findings reveal that light- and darkness-induced daily bursts of norepinephrine, TNF, and melatonin within the BM are essential for synchronized mature blood cell production and HSPC pool repopulation.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.subjectHematopoietic Stem Cells
dc.subjectCells, Cultured
dc.subjectAnimals
dc.subjectMice, Inbred C57BL
dc.subjectMice
dc.subjectTranscription Factors
dc.subjectCell Differentiation
dc.subjectEpigenesis, Genetic
dc.subjectLight
dc.subjectDarkness
dc.titleDaily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance.
dc.typeArticle
prism.endingPage585.e7
prism.issueIdentifier4
prism.publicationDate2018
prism.publicationNameCell Stem Cell
prism.startingPage572
prism.volume23
dc.identifier.doi10.17863/CAM.32901
dcterms.dateAccepted2018-08-06
rioxxterms.versionofrecord10.1016/j.stem.2018.08.002
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-10
dc.contributor.orcidFerreira, Zulma S [0000-0001-6571-837X]
dc.contributor.orcidRzeszotek, Sylwia [0000-0002-2157-0315]
dc.contributor.orcidXie, Stephanie [0000-0002-0284-494X]
dc.contributor.orcidFlores-Figueroa, Eugenia [0000-0002-7453-1125]
dc.contributor.orcidGur-Cohen, Shiri [0000-0002-6372-2284]
dc.contributor.orcidCiechanowicz, Andrzej K [0000-0003-0052-136X]
dc.contributor.orcidRatajczak, Mariusz Z [0000-0002-0071-0198]
dc.contributor.orcidMéndez-Ferrer, Simón [0000-0002-9805-9988]
dc.identifier.eissn1875-9777
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Research Council (648765)
pubs.funder-project-idNHS Blood and Transplant (NHSBT)
pubs.funder-project-idMedical Research Council (MC_PC_12009)
rioxxterms.freetoread.startdate2019-10-31


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