Polygenic Risk Score for Schizophrenia and Face-Processing Network in Young Adulthood.
Kiviniemi, Vesa J
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Lieslehto, J., Kiviniemi, V. J., Nordström, T., Barnett, J., Murray, G., Jones, P., Paus, T., & et al. (2019). Polygenic Risk Score for Schizophrenia and Face-Processing Network in Young Adulthood.. Schizophrenia bulletin, 45 (4), 835-845. https://doi.org/10.1093/schbul/sby139
Development of schizophrenia relates to both genetic and environmental factors. Functional deficits in many cognitive domains, including the ability to communicate in social interactions and impaired recognition of facial expressions, is common for patients with schizophrenia and might also be present in individuals at risk of developing schizophrenia. Here we explore whether an individual’s polygenic risk score for schizophrenia (PRS) is associated with the degree of interregional similarities in BOLD signal and grey matter volume of the face-processing network and whether the exposure to early adversity moderates this association. A total of 90 individuals (mean age 22 years, both functional and structural data available) were used for discovery analyses, and 211 individuals (mean age 26, structural data available) were used for replication of the structural findings. Both samples were drawn from the Northern Finland Birth Cohort 1986. We found that the degree of interregional similarities in BOLD signal and grey matter volume vary as a function of PRS; lowest interregional correlation (both measures) is observed in individuals with high PRS. We also replicated the grey matter volume finding. We did not find evidence for an interaction between early adversity and PRS on the interregional correlation of BOLD signal and grey matter volume. We speculate that the observed group differences in PRS-related correlations in both modalities may result from differences in the concurrent functional engagement of the face-processing regions over time, for example via differences in exposure to social interaction with other people.
Humans, Genetic Predisposition to Disease, Magnetic Resonance Imaging, Facial Expression, Brain Mapping, Registries, Risk, Cohort Studies, Social Perception, Schizophrenia, Adult, Finland, Female, Male, Genome-Wide Association Study, Young Adult, Gray Matter, Facial Recognition, Adverse Childhood Experiences
Funding: The study was funded by grants from The Finnish Medical Association (author JL), Yrjö Jahnsson’s Foundation (author JL), Psykiatrian tutkimussäätiö (Finnish Foundation for Psychiatric Research), Jalmari and Rauha Ahokas Foundation, Academy of Finland (#124257, #212818, #214273) (author JV), the Sigrid Juselius Foundation (author JV), the Signe and Ane Gyllenberg Foundation, Finland (author JV), the Alfred Kordelin Foundation (author JL), the Orion Foundation (author JL).
External DOI: https://doi.org/10.1093/schbul/sby139
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285547
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/