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dc.contributor.authorLieslehto, Johannes
dc.contributor.authorKiviniemi, Vesa J
dc.contributor.authorNordström, Tanja
dc.contributor.authorBarnett, Jennifer
dc.contributor.authorMurray, Graham
dc.contributor.authorJones, Peter
dc.contributor.authorPaus, Tomáš
dc.contributor.authorVeijola, Juha
dc.date.accessioned2018-11-21T00:31:36Z
dc.date.available2018-11-21T00:31:36Z
dc.date.issued2019-06-18
dc.identifier.issn0586-7614
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285547
dc.description.abstractDevelopment of schizophrenia relates to both genetic and environmental factors. Functional deficits in many cognitive domains, including the ability to communicate in social interactions and impaired recognition of facial expressions, are common for patients with schizophrenia and might also be present in individuals at risk of developing schizophrenia. Here we explore whether an individual's polygenic risk score (PRS) for schizophrenia is associated with the degree of interregional similarities in blood oxygen level-dependent (BOLD) signal and gray matter volume of the face-processing network and whether the exposure to early adversity moderates this association. A total of 90 individuals (mean age 22 years, both functional and structural data available) were used for discovery analyses, and 211 individuals (mean age 26 years, structural data available) were used for replication of the structural findings. Both samples were drawn from the Northern Finland Birth Cohort 1986. We found that the degree of interregional similarities in BOLD signal and gray matter volume vary as a function of PRS; lowest interregional correlation (both measures) was observed in individuals with high PRS. We also replicated the gray matter volume finding. We did not find evidence for an interaction between early adversity and PRS on the interregional correlation of BOLD signal and gray matter volume. We speculate that the observed group differences in PRS-related correlations in both modalities may result from differences in the concurrent functional engagement of the face-processing regions over time, eg, via differences in exposure to social interaction with other people.
dc.description.sponsorshipFunding: The study was funded by grants from The Finnish Medical Association (author JL), Yrjö Jahnsson’s Foundation (author JL), Psykiatrian tutkimussäätiö (Finnish Foundation for Psychiatric Research), Jalmari and Rauha Ahokas Foundation, Academy of Finland (#124257, #212818, #214273) (author JV), the Sigrid Juselius Foundation (author JV), the Signe and Ane Gyllenberg Foundation, Finland (author JV), the Alfred Kordelin Foundation (author JL), the Orion Foundation (author JL).
dc.format.mediumPrint
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectHumans
dc.subjectGenetic Predisposition to Disease
dc.subjectMagnetic Resonance Imaging
dc.subjectFacial Expression
dc.subjectBrain Mapping
dc.subjectRegistries
dc.subjectRisk
dc.subjectCohort Studies
dc.subjectSocial Perception
dc.subjectSchizophrenia
dc.subjectAdult
dc.subjectFinland
dc.subjectFemale
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.subjectYoung Adult
dc.subjectGray Matter
dc.subjectFacial Recognition
dc.subjectAdverse Childhood Experiences
dc.titlePolygenic Risk Score for Schizophrenia and Face-Processing Network in Young Adulthood.
dc.typeArticle
prism.endingPage845
prism.issueIdentifier4
prism.publicationDate2019
prism.publicationNameSchizophr Bull
prism.startingPage835
prism.volume45
dc.identifier.doi10.17863/CAM.32904
dcterms.dateAccepted2018-09-12
rioxxterms.versionofrecord10.1093/schbul/sby139
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-06
dc.contributor.orcidMurray, Graham [0000-0001-8296-1742]
dc.contributor.orcidJones, Peter [0000-0002-0387-880X]
dc.identifier.eissn1745-1701
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-10-03


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International