Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server.
Angew Chem Int Ed Engl
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Fitzpatrick, D. E., Maujean, T., Evans, A. C., & Ley, S. V. (2018). Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server.. Angew Chem Int Ed Engl, 57 (46), 15128-15132. https://doi.org/10.1002/anie.201809080
The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples.
Tramadol, Lidocaine, Bupropion, Analgesics, Opioid, Anesthetics, Local, Antidepressive Agents, Second-Generation, Equipment Design, Drug Industry, United States, Japan, Chemistry Techniques, Synthetic, Cloud Computing, United Kingdom
Woolf Fisher Trust (DEF), EPSRC (SVL; grant codes EP/K009494/1, EP/K039520/1 and EP/M004120/1) and H2020-FETOPEN-2016-2017 programme of European commission (DEF, SVL; grant agreement number: 737266-ONE FLOW).
Engineering and Physical Sciences Research Council (EP/M004120/1)
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (737266)
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
External DOI: https://doi.org/10.1002/anie.201809080
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285602