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Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Fitzpatrick, Daniel E  ORCID logo  https://orcid.org/0000-0003-3462-1852
Maujean, Timothé 

Abstract

The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples.

Description

Keywords

continuous synthesis, flow chemistry, self-optimization, Analgesics, Opioid, Anesthetics, Local, Antidepressive Agents, Second-Generation, Bupropion, Chemistry Techniques, Synthetic, Cloud Computing, Drug Industry, Equipment Design, Japan, Lidocaine, Tramadol, United Kingdom, United States

Journal Title

Angew Chem Int Ed Engl

Conference Name

Journal ISSN

1433-7851
1521-3773

Volume Title

57

Publisher

Wiley
Sponsorship
Engineering and Physical Sciences Research Council (EP/M004120/1)
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (737266)
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Woolf Fisher Trust (DEF), EPSRC (SVL; grant codes EP/K009494/1, EP/K039520/1 and EP/M004120/1) and H2020-FETOPEN-2016-2017 programme of European commission (DEF, SVL; grant agreement number: 737266-ONE FLOW).