Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server.

Fitzpatrick, Daniel E; Maujean, Timothé; Evans, Amanda C; Ley, Steven V

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Authors

Fitzpatrick, Daniel E

Maujean, Timothé

Evans, Amanda C

Ley, Steven V

Publication Date

2018-11-12

Journal Title

Angew Chem Int Ed Engl

ISSN

1433-7851

Publisher

Wiley

Volume

Issue

Pages

15128-15132

Language

eng

Type

Article

Physical Medium

Print-Electronic

Metadata

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Citation

Fitzpatrick, D. E., Maujean, T., Evans, A. C., & Ley, S. V. (2018). Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server.. Angew Chem Int Ed Engl, 57 (46), 15128-15132. https://doi.org/10.1002/anie.201809080

Abstract

The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples.

Keywords

continuous synthesis, flow chemistry, self-optimization, Analgesics, Opioid, Anesthetics, Local, Antidepressive Agents, Second-Generation, Bupropion, Chemistry Techniques, Synthetic, Cloud Computing, Drug Industry, Equipment Design, Japan, Lidocaine, Tramadol, United Kingdom, United States

Sponsorship

Woolf Fisher Trust (DEF), EPSRC (SVL; grant codes EP/K009494/1, EP/K039520/1 and EP/M004120/1) and H2020-FETOPEN-2016-2017 programme of European commission (DEF, SVL; grant agreement number: 737266-ONE FLOW).

Funder references

Engineering and Physical Sciences Research Council (EP/M004120/1)

European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (737266)

Engineering and Physical Sciences Research Council (EP/K009494/1)

Engineering and Physical Sciences Research Council (EP/K039520/1)

Identifiers

External DOI: https://doi.org/10.1002/anie.201809080

This record's URL: https://www.repository.cam.ac.uk/handle/1810/285602

Rights

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http://www.rioxx.net/licenses/all-rights-reserved

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