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dc.contributor.authorChow, Wing Ying
dc.contributor.authorLi, Rui
dc.contributor.authorGoldberga, Ieva
dc.contributor.authorReid, David G
dc.contributor.authorRajan, Rakesh
dc.contributor.authorClark, Jonathan
dc.contributor.authorOschkinat, Hartmut
dc.contributor.authorDuer, Melinda J
dc.contributor.authorHayward, Robert
dc.contributor.authorShanahan, Catherine M
dc.date.accessioned2018-11-22T00:31:49Z
dc.date.available2018-11-22T00:31:49Z
dc.date.issued2018-11-06
dc.identifier.issn1359-7345
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285636
dc.description.abstractThe sparse but functionally essential post-translational collagen modification 5-hydroxylysine can undergo further transformations, including crosslinking, O-glycosylation, and glycation. Dynamic nuclear polarization (DNP) and stable isotope enriched lysine incorporation provide sufficient solid-state NMR sensitivity to identify these adducts directly in skin and vascular smooth muscle cell extracellular matrix (ECM), without extraction procedures, by comparison with chemical shifts of model compounds. Thus, DNP provides access to the elucidation of structural consequences of collagen modifications in intact tissue.
dc.format.mediumPrint
dc.languageeng
dc.publisherRoyal Society of Chemistry (RSC)
dc.titleEssential but sparse collagen hydroxylysyl post-translational modifications detected by DNP NMR.
dc.typeArticle
prism.endingPage12573
prism.issueIdentifier89
prism.publicationDate2018
prism.publicationNameChem Commun (Camb)
prism.startingPage12570
prism.volume54
dc.identifier.doi10.17863/CAM.32989
dcterms.dateAccepted2018-10-02
rioxxterms.versionofrecord10.1039/c8cc04960b
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-11
dc.contributor.orcidChow, Wing Ying [0000-0003-0719-5958]
dc.contributor.orcidGoldberga, Ieva [0000-0003-4284-3527]
dc.contributor.orcidReid, David G [0000-0003-2464-5295]
dc.identifier.eissn1364-548X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEPSRC (1652492)
pubs.funder-project-idMedical Research Council (MR/M01066X/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/G021392/1)
cam.issuedOnline2018
datacite.issupplementedby.urlhttps://doi.org/10.17863/CAM.30578
rioxxterms.freetoread.startdate2019-10-05


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