Sarcoidosis following alemtuzumab treatment for multiple sclerosis
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Jones, J., Willis, M., & Coles, A. (2018). Sarcoidosis following alemtuzumab treatment for multiple sclerosis. Multiple Sclerosis https://doi.org/10.1177/1352458518790391
Despite proven efficacy of alemtuzumab in multiple sclerosis (MS), approximately 50% of individuals will develop a new autoimmune disease following treatment. To date these have largely been antibody mediated and organ specific (primarily affecting the thyroid gland). In a retrospective case series of 187 patients from two UK specialist centres (Cardiff and Cambridge) followed up for a median of 10 years, we report 3 (1.6%) cases of sarcoidosis following alemtuzumab treatment of MS. This report increases the spectrum of auto-inflammatory disease following alemtuzumab and should be considered by clinicians when using this therapeutic agent for MS.
Medical Research Council (G1100114)
External DOI: https://doi.org/10.1177/1352458518790391
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285728