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dc.contributor.authorHuhtaniska, Sanna
dc.contributor.authorKorkala, Iikka
dc.contributor.authorHeikka, Tuomas
dc.contributor.authorBjörnholm, Lassi
dc.contributor.authorLehtiniemi, Heli
dc.contributor.authorHulkko, Anja P
dc.contributor.authorMoilanen, Jani
dc.contributor.authorTohka, Jussi
dc.contributor.authorManjón, José
dc.contributor.authorCoupé, Pierrick
dc.contributor.authorKiviniemi, Vesa
dc.contributor.authorIsohanni, Matti
dc.contributor.authorKoponen, Hannu
dc.contributor.authorMurray, Graham
dc.contributor.authorMiettunen, Jouko
dc.contributor.authorJääskeläinen, Erika
dc.date.accessioned2018-11-23T00:31:38Z
dc.date.available2018-11-23T00:31:38Z
dc.date.issued2018-11-30
dc.identifier.issn0925-4927
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285787
dc.description.abstractThe aim of this paper was to investigate differences in brain structure volumes between schizophrenia and affective psychoses, and whether cumulative lifetime antipsychotic or benzodiazepine doses relate to brain morphology in these groups. We conducted two systematic reviews on the topic and investigated 44 schizophrenia cases and 19 with affective psychoses from the Northern Finland Birth Cohort 1966. The association between lifetime antipsychotic and benzodiazepine dose and brain MRI scans at the age of 43 was investigated using linear regression. Intracranial volume, sex, illness severity, and antipsychotic/benzodiazepine doses were used as covariates. There were no differences between the groups in brain structure volumes. In schizophrenia, after adjusting for benzodiazepine dose and symptoms, a negative association between lifetime antipsychotic dose and the nucleus accumbens volume remained. In affective psychoses, higher lifetime benzodiazepine dose associated with larger volumes of total gray matter and hippocampal volume after controlling for antipsychotic use and symptoms. It seems that in addition to antipsychotics, the severity of symptoms and benzodiazepine dose are also associated with brain structure volumes. These results suggest, that benzodiazepine effects should also be investigated also independently and not only as a confounder.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.subjectBrain
dc.subjectHumans
dc.subjectBenzodiazepines
dc.subjectAntipsychotic Agents
dc.subjectMagnetic Resonance Imaging
dc.subjectOrgan Size
dc.subjectLinear Models
dc.subjectCohort Studies
dc.subjectAffective Disorders, Psychotic
dc.subjectSchizophrenia
dc.subjectAdult
dc.subjectFinland
dc.subjectFemale
dc.subjectMale
dc.titleAntipsychotic and benzodiazepine use and brain morphology in schizophrenia and affective psychoses - Systematic reviews and birth cohort study.
dc.typeArticle
prism.endingPage52
prism.publicationDate2018
prism.publicationNamePsychiatry Res Neuroimaging
prism.startingPage43
prism.volume281
dc.identifier.doi10.17863/CAM.33131
dcterms.dateAccepted2018-08-23
rioxxterms.versionofrecord10.1016/j.pscychresns.2018.08.015
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-11
dc.contributor.orcidMurray, Graham [0000-0001-8296-1742]
dc.identifier.eissn1872-7506
rioxxterms.typeJournal Article/Review
rioxxterms.freetoread.startdate2019-11-30


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