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dc.contributor.authorZheng, Wei
dc.contributor.authorLi, Qian
dc.contributor.authorZhao, Chao
dc.contributor.authorDa, Yuwei
dc.contributor.authorZhang, Hong-Liang
dc.contributor.authorChen, Zhiguo
dc.date.accessioned2018-11-23T00:31:56Z
dc.date.available2018-11-23T00:31:56Z
dc.date.issued2018
dc.identifier.issn1662-5102
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285799
dc.description.abstractGlial cells are the most abundant cell type in the central nervous system (CNS) and play essential roles in maintaining brain homeostasis, forming myelin, and providing support and protection for neurons, etc. Over the past decade, significant progress has been made in the reprogramming field. Given the limited accessibility of human glial cells, in vitro differentiation of human induced pluripotent stem cells (hiPSCs) into glia may provide not only a valuable research tool for a better understanding of the functions of glia in the CNS but also a potential cellular source for clinical therapeutic purposes. In this review, we will summarize up-to-date novel strategies for the committed differentiation into the three major glial cell types, i.e., astrocyte, oligodendrocyte, and microglia, from hiPSCs, focusing on the non-neuronal cell effects on the pathology of some representative neurological diseases. Furthermore, the application of hiPSC-derived glial cells in neurological disease modeling will be discussed, so as to gain further insights into the development of new therapeutic targets for treatment of neurological disorders.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherFrontiers Media SA
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleDifferentiation of Glial Cells From hiPSCs: Potential Applications in Neurological Diseases and Cell Replacement Therapy.
dc.typeArticle
prism.publicationDate2018
prism.publicationNameFront Cell Neurosci
prism.startingPage239
prism.volume12
dc.identifier.doi10.17863/CAM.33143
dcterms.dateAccepted2018-07-17
rioxxterms.versionofrecord10.3389/fncel.2018.00239
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-01
dc.contributor.orcidZhao, Chao [0000-0003-1144-1621]
dc.identifier.eissn1662-5102
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-08-08


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International