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dc.contributor.authorCarreira-Rosario, Arnaldo
dc.contributor.authorZarin, Aref Arzan
dc.contributor.authorClark, Matthew Q
dc.contributor.authorManning, Laurina
dc.contributor.authorFetter, Richard D
dc.contributor.authorCardona, Albert
dc.contributor.authorDoe, Chris Q
dc.date.accessioned2018-11-23T00:32:20Z
dc.date.available2018-11-23T00:32:20Z
dc.date.issued2018-08-02
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285814
dc.description.abstractCommand-like descending neurons can induce many behaviors, such as backward locomotion, escape, feeding, courtship, egg-laying, or grooming (we define 'command-like neuron' as a neuron whose activation elicits or 'commands' a specific behavior). In most animals, it remains unknown how neural circuits switch between antagonistic behaviors: via top-down activation/inhibition of antagonistic circuits or via reciprocal inhibition between antagonistic circuits. Here, we use genetic screens, intersectional genetics, circuit reconstruction by electron microscopy, and functional optogenetics to identify a bilateral pair of Drosophila larval 'mooncrawler descending neurons' (MDNs) with command-like ability to coordinately induce backward locomotion and block forward locomotion; the former by stimulating a backward-active premotor neuron, and the latter by disynaptic inhibition of a forward-specific premotor neuron. In contrast, direct monosynaptic reciprocal inhibition between forward and backward circuits was not observed. Thus, MDNs coordinate a transition between antagonistic larval locomotor behaviors. Interestingly, larval MDNs persist into adulthood, where they can trigger backward walking. Thus, MDNs induce backward locomotion in both limbless and limbed animals.
dc.format.mediumElectronic
dc.languageeng
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBrain
dc.subjectMotor Neurons
dc.subjectAnimals
dc.subjectDrosophila melanogaster
dc.subjectDrosophila Proteins
dc.subjectLarva
dc.subjectLocomotion
dc.subjectModels, Biological
dc.subjectConnectome
dc.titleMDN brain descending neurons coordinately activate backward and inhibit forward locomotion.
dc.typeArticle
prism.publicationDate2018
prism.publicationNameElife
prism.volume7
dc.identifier.doi10.17863/CAM.33158
dcterms.dateAccepted2018-07-28
rioxxterms.versionofrecord10.7554/eLife.38554
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-08-02
dc.contributor.orcidZarin, Aref Arzan [0000-0003-0484-3622]
dc.contributor.orcidClark, Matthew Q [0000-0002-1113-9388]
dc.contributor.orcidFetter, Richard D [0000-0002-1558-100X]
dc.contributor.orcidCardona, Albert [0000-0003-4941-6536]
dc.contributor.orcidDoe, Chris Q [0000-0001-5980-8029]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-08-02


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International