A new era in palaeomicrobiology: prospects for ancient dental calculus as a long-term record of the human oral microbiome.
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Publication Date
2015-01-19Journal Title
Philos Trans R Soc Lond B Biol Sci
ISSN
0962-8436
Publisher
The Royal Society
Volume
370
Issue
1660
Pages
20130376
Language
eng
Type
Article
Physical Medium
Print
Metadata
Show full item recordCitation
Warinner, C., Speller, C., & Collins, M. J. (2015). A new era in palaeomicrobiology: prospects for ancient dental calculus as a long-term record of the human oral microbiome.. Philos Trans R Soc Lond B Biol Sci, 370 (1660), 20130376. https://doi.org/10.1098/rstb.2013.0376
Abstract
The field of palaeomicrobiology is dramatically expanding thanks to recent advances in high-throughput biomolecular sequencing, which allows unprecedented access to the evolutionary history and ecology of human-associated and environmental microbes. Recently, human dental calculus has been shown to be an abundant, nearly ubiquitous, and long-term reservoir of the ancient oral microbiome, preserving not only microbial and host biomolecules but also dietary and environmental debris. Modern investigations of native human microbiota have demonstrated that the human microbiome plays a central role in health and chronic disease, raising questions about changes in microbial ecology, diversity and function through time. This paper explores the current state of ancient oral microbiome research and discusses successful applications, methodological challenges and future possibilities in elucidating the intimate evolutionary relationship between humans and their microbes.
Keywords
ancient DNA, dental calculus, metagenomics, metaproteomics, oral microbiome, palaeomicrobiology, Archaeology, Dental Calculus, Fossils, High-Throughput Nucleotide Sequencing, Humans, Microbiological Techniques, Microbiota, Paleodontology
Identifiers
External DOI: https://doi.org/10.1098/rstb.2013.0376
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285852
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