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dc.contributor.authorDemarchi, Beatrice
dc.contributor.authorHall, Shaun
dc.contributor.authorRoncal-Herrero, Teresa
dc.contributor.authorFreeman, Colin L
dc.contributor.authorWoolley, Jos
dc.contributor.authorCrisp, Molly K
dc.contributor.authorWilson, Julie
dc.contributor.authorFotakis, Anna
dc.contributor.authorFischer, Roman
dc.contributor.authorKessler, Benedikt M
dc.contributor.authorRakownikow Jersie-Christensen, Rosa
dc.contributor.authorOlsen, Jesper V
dc.contributor.authorHaile, James
dc.contributor.authorThomas, Jessica
dc.contributor.authorMarean, Curtis W
dc.contributor.authorParkington, John
dc.contributor.authorPresslee, Samantha
dc.contributor.authorLee-Thorp, Julia
dc.contributor.authorDitchfield, Peter
dc.contributor.authorHamilton, Jacqueline F
dc.contributor.authorWard, Martyn W
dc.contributor.authorWang, Chunting Michelle
dc.contributor.authorShaw, Marvin D
dc.contributor.authorHarrison, Terry
dc.contributor.authorDomínguez-Rodrigo, Manuel
dc.contributor.authorMacPhee, Ross DE
dc.contributor.authorKwekason, Amandus
dc.contributor.authorEcker, Michaela
dc.contributor.authorKolska Horwitz, Liora
dc.contributor.authorChazan, Michael
dc.contributor.authorKröger, Roland
dc.contributor.authorThomas-Oates, Jane
dc.contributor.authorHarding, John H
dc.contributor.authorCappellini, Enrico
dc.contributor.authorPenkman, Kirsty
dc.contributor.authorCollins, Matthew J
dc.date.accessioned2018-11-23T00:33:20Z
dc.date.available2018-11-23T00:33:20Z
dc.date.issued2016-09-27
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285855
dc.description.abstractProteins persist longer in the fossil record than DNA, but the longevity, survival mechanisms and substrates remain contested. Here, we demonstrate the role of mineral binding in preserving the protein sequence in ostrich (Struthionidae) eggshell, including from the palaeontological sites of Laetoli (3.8 Ma) and Olduvai Gorge (1.3 Ma) in Tanzania. By tracking protein diagenesis back in time we find consistent patterns of preservation, demonstrating authenticity of the surviving sequences. Molecular dynamics simulations of struthiocalcin-1 and -2, the dominant proteins within the eggshell, reveal that distinct domains bind to the mineral surface. It is the domain with the strongest calculated binding energy to the calcite surface that is selectively preserved. Thermal age calculations demonstrate that the Laetoli and Olduvai peptides are 50 times older than any previously authenticated sequence (equivalent to ~16 Ma at a constant 10°C).
dc.format.mediumElectronic
dc.languageeng
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleProtein sequences bound to mineral surfaces persist into deep time.
dc.typeArticle
prism.publicationDate2016
prism.publicationNameElife
prism.volume5
dc.identifier.doi10.17863/CAM.33199
dcterms.dateAccepted2016-08-17
rioxxterms.versionofrecord10.7554/eLife.17092
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-09-27
dc.contributor.orcidDemarchi, Beatrice [0000-0002-8398-4409]
dc.contributor.orcidEcker, Michaela [0000-0001-9581-1882]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idDirectorate for Biological Sciences (1547414)
pubs.funder-project-idArts and Humanities Research Council (AH/L006979/1)
pubs.funder-project-idNatural Environment Research Council (NE/G004625/1)
cam.issuedOnline2016-09-27


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International