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dc.contributor.authorMackie, Meaghan
dc.contributor.authorHendy, Jessica
dc.contributor.authorLowe, Abigail D
dc.contributor.authorSperduti, Alessandra
dc.contributor.authorHolst, Malin
dc.contributor.authorCollins, Matthew
dc.contributor.authorSpeller, Camilla F
dc.date.accessioned2018-11-23T00:33:26Z
dc.date.available2018-11-23T00:33:26Z
dc.date.issued2017
dc.identifier.issn2054-8923
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285859
dc.description.abstractProteomic analysis of dental calculus is emerging as a powerful tool for disease and dietary characterisation of archaeological populations. To better understand the variability in protein results from dental calculus, we analysed 21 samples from three Roman-period populations to compare: 1) the quantity of extracted protein; 2) the number of mass spectral queries; and 3) the number of peptide spectral matches and protein identifications. We found little correlation between the quantity of calculus analysed and total protein identifications, as well as no systematic trends between site location and protein preservation. We identified a wide range of individual variability, which may be associated with the mechanisms of calculus formation and/or post-depositional contamination, in addition to taphonomic factors. Our results suggest dental calculus is indeed a stable, long-term reservoir of proteins as previously reported, but further systematic studies are needed to identify mechanisms associated with protein entrapment and survival in dental calculus.
dc.format.mediumElectronic-eCollection
dc.languageeng
dc.publisherInforma UK Limited
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titlePreservation of the metaproteome: variability of protein preservation in ancient dental calculus.
dc.typeArticle
prism.endingPage86
prism.issueIdentifier1
prism.publicationDate2017
prism.publicationNameSci Technol Archaeol Res
prism.startingPage74
prism.volume3
dc.identifier.doi10.17863/CAM.33203
dcterms.dateAccepted2017-07-16
rioxxterms.versionofrecord10.1080/20548923.2017.1361629
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-01
dc.contributor.orcidMackie, Meaghan [0000-0003-0763-7592]
dc.contributor.orcidHendy, Jessica [0000-0002-3718-1058]
dc.contributor.orcidLowe, Abigail D [0000-0001-5132-007X]
dc.contributor.orcidCollins, Matthew [0000-0003-4226-5501]
dc.contributor.orcidSpeller, Camilla F [0000-0001-7128-9903]
dc.identifier.eissn2054-8923
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-08-11


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International