Pathogens and host immunity in the ancient human oral cavity.
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Authors
Warinner, Christina
Rodrigues, João F Matias
Vyas, Rounak
Trachsel, Christian
Shved, Natallia
Grossmann, Jonas
Radini, Anita
Hancock, Y
Tito, Raul Y
Speller, Camilla
Hendy, Jessica
Charlton, Sophy
Luder, Hans Ulrich
Salazar-García, Domingo C
Eppler, Elisabeth
Seiler, Roger
Hansen, Lars H
Castruita, José Alfredo Samaniego
Barkow-Oesterreicher, Simon
Teoh, Kai Yik
Kelstrup, Christian D
Olsen, Jesper V
Nanni, Paolo
Kawai, Toshihisa
von Mering, Christian
Lewis, Cecil M
Collins, Matthew J
Gilbert, M Thomas P
Rühli, Frank
Cappellini, Enrico
Publication Date
2014-04Journal Title
Nat Genet
ISSN
1061-4036
Publisher
Springer Science and Business Media LLC
Volume
46
Issue
4
Pages
336-344
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Warinner, C., Rodrigues, J. F. M., Vyas, R., Trachsel, C., Shved, N., Grossmann, J., Radini, A., et al. (2014). Pathogens and host immunity in the ancient human oral cavity.. Nat Genet, 46 (4), 336-344. https://doi.org/10.1038/ng.2906
Abstract
Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human-associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, 'red complex' pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past.
Keywords
Mouth, Dental Calculus, Humans, Bacteroidetes, Proteome, RNA, Ribosomal, 16S, Food Analysis, Sequence Analysis, DNA, Phylogeny, Base Sequence, Genome, Bacterial, Archaeology, History, Medieval, Molecular Sequence Data, Germany, Tandem Mass Spectrometry, Microbiota
Identifiers
External DOI: https://doi.org/10.1038/ng.2906
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285861
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http://www.rioxx.net/licenses/all-rights-reserved
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