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dc.contributor.authorHampras, Shalaka S
dc.contributor.authorSucheston-Campbell, Lara E
dc.contributor.authorCannioto, Rikki
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorModugno, Francesmary
dc.contributor.authorDörk, Thilo
dc.contributor.authorHillemanns, Peter
dc.contributor.authorPreus, Leah
dc.contributor.authorKnutson, Keith L
dc.contributor.authorWallace, Paul K
dc.contributor.authorHong, Chi-Chen
dc.contributor.authorFriel, Grace
dc.contributor.authorDavis, Warren
dc.contributor.authorNesline, Mary
dc.contributor.authorPearce, Celeste L
dc.contributor.authorKelemen, Linda E
dc.contributor.authorGoodman, Marc T
dc.contributor.authorBandera, Elisa V
dc.contributor.authorTerry, Kathryn L
dc.contributor.authorSchoof, Nils
dc.contributor.authorEng, Kevin H
dc.contributor.authorClay, Alyssa
dc.contributor.authorSingh, Prashant K
dc.contributor.authorJoseph, Janine M
dc.contributor.authorAben, Katja KH
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorAntonenkova, Natalia
dc.contributor.authorBaker, Helen
dc.contributor.authorBean, Yukie
dc.contributor.authorBeckmann, Matthias W
dc.contributor.authorBisogna, Maria
dc.contributor.authorBjorge, Line
dc.contributor.authorBogdanova, Natalia
dc.contributor.authorBrinton, Louise A
dc.contributor.authorBrooks-Wilson, Angela
dc.contributor.authorBruinsma, Fiona
dc.contributor.authorButzow, Ralf
dc.contributor.authorCampbell, Ian G
dc.contributor.authorCarty, Karen
dc.contributor.authorCook, Linda S
dc.contributor.authorCramer, Daniel W
dc.contributor.authorCybulski, Cezary
dc.contributor.authorDansonka-Mieszkowska, Agnieszka
dc.contributor.authorDennis, Joe
dc.contributor.authorDespierre, Evelyn
dc.contributor.authorDicks, Ed
dc.contributor.authorDoherty, Jennifer A
dc.contributor.authordu Bois, Andreas
dc.contributor.authorDürst, Matthias
dc.contributor.authorEaston, Doug
dc.contributor.authorEccles, Diana
dc.contributor.authorEdwards, Robert P
dc.contributor.authorEkici, Arif B
dc.contributor.authorFasching, Peter A
dc.contributor.authorFridley, Brooke L
dc.contributor.authorGao, Yu-Tang
dc.contributor.authorGentry-Maharaj, Aleksandra
dc.contributor.authorGiles, Graham G
dc.contributor.authorGlasspool, Rosalind
dc.contributor.authorGronwald, Jacek
dc.contributor.authorHarrington, Patricia
dc.contributor.authorHarter, Philipp
dc.contributor.authorHasmad, Hanis Nazihah
dc.contributor.authorHein, Alexander
dc.contributor.authorHeitz, Florian
dc.contributor.authorHildebrandt, Michelle AT
dc.contributor.authorHogdall, Claus
dc.contributor.authorHogdall, Estrid
dc.contributor.authorHosono, Satoyo
dc.contributor.authorIversen, Edwin S
dc.contributor.authorJakubowska, Anna
dc.contributor.authorJensen, Allan
dc.contributor.authorJi, Bu-Tian
dc.contributor.authorKarlan, Beth Y
dc.contributor.authorKellar, Melissa
dc.contributor.authorKelley, Joseph L
dc.contributor.authorKiemeney, Lambertus A
dc.contributor.authorKlapdor, Rüdiger
dc.contributor.authorKolomeyevskaya, Nonna
dc.contributor.authorKrakstad, Camilla
dc.contributor.authorKjaer, Susanne K
dc.contributor.authorKruszka, Bridget
dc.contributor.authorKupryjanczyk, Jolanta
dc.contributor.authorLambrechts, Diether
dc.contributor.authorLambrechts, Sandrina
dc.contributor.authorLe, Nhu D
dc.contributor.authorLee, Alice W
dc.contributor.authorLele, Shashikant
dc.contributor.authorLeminen, Arto
dc.contributor.authorLester, Jenny
dc.contributor.authorLevine, Douglas A
dc.contributor.authorLiang, Dong
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorLiu, Song
dc.contributor.authorLu, Karen
dc.contributor.authorLubinski, Jan
dc.contributor.authorLundvall, Lene
dc.contributor.authorMassuger, Leon FAG
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorMcGuire, Valeria
dc.contributor.authorMcLaughlin, John R
dc.contributor.authorMcNeish, Ian
dc.contributor.authorMenon, Usha
dc.contributor.authorMoes-Sosnowska, Joanna
dc.contributor.authorNarod, Steven A
dc.contributor.authorNedergaard, Lotte
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorNickels, Stefan
dc.contributor.authorOlson, Sara H
dc.contributor.authorOrlow, Irene
dc.contributor.authorWeber, Rachel Palmieri
dc.contributor.authorPaul, James
dc.contributor.authorPejovic, Tanja
dc.contributor.authorPelttari, Liisa M
dc.contributor.authorPerkins, Barbara
dc.contributor.authorPermuth-Wey, Jenny
dc.contributor.authorPike, Malcolm C
dc.contributor.authorPlisiecka-Halasa, Joanna
dc.contributor.authorPoole, Elizabeth M
dc.contributor.authorRisch, Harvey A
dc.contributor.authorRossing, Mary Anne
dc.contributor.authorRothstein, Joseph H
dc.contributor.authorRudolph, Anja
dc.contributor.authorRunnebaum, Ingo B
dc.contributor.authorRzepecka, Iwona K
dc.contributor.authorSalvesen, Helga B
dc.contributor.authorSchernhammer, Eva
dc.contributor.authorSchmitt, Kristina
dc.contributor.authorSchwaab, Ira
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorShvetsov, Yurii B
dc.contributor.authorSiddiqui, Nadeem
dc.contributor.authorSieh, Weiva
dc.contributor.authorSong, Honglin
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorTangen, Ingvild L
dc.contributor.authorTeo, Soo-Hwang
dc.contributor.authorThompson, Pamela J
dc.contributor.authorTimorek, Agnieszka
dc.contributor.authorTsai, Ya-Yu
dc.contributor.authorTworoger, Shelley S
dc.contributor.authorTyrer, Jonathan
dc.contributor.authorvan Altena, Anna M
dc.contributor.authorVergote, Ignace
dc.contributor.authorVierkant, Robert A
dc.contributor.authorWalsh, Christine
dc.contributor.authorWang-Gohrke, Shan
dc.contributor.authorWentzensen, Nicolas
dc.contributor.authorWhittemore, Alice S
dc.contributor.authorWicklund, Kristine G
dc.contributor.authorWilkens, Lynne R
dc.contributor.authorWu, Anna H
dc.contributor.authorWu, Xifeng
dc.contributor.authorWoo, Yin-Ling
dc.contributor.authorYang, Hannah
dc.contributor.authorZheng, Wei
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorGayther, Simon A
dc.contributor.authorRamus, Susan J
dc.contributor.authorSellers, Thomas A
dc.contributor.authorSchildkraut, Joellen M
dc.contributor.authorPhelan, Catherine M
dc.contributor.authorBerchuck, Andrew
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorCunningham, Julie M
dc.contributor.authorPharoah, Paul P
dc.contributor.authorNess, Roberta B
dc.contributor.authorOdunsi, Kunle
dc.contributor.authorGoode, Ellen L
dc.contributor.authorMoysich, Kirsten B
dc.date.accessioned2018-11-24T00:30:49Z
dc.date.available2018-11-24T00:30:49Z
dc.date.issued2016-10-25
dc.identifier.issn1949-2553
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285923
dc.description.abstractBACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer. METHODS: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients. RESULTS: The most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively). CONCLUSIONS: Common inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients.
dc.languageeng
dc.publisherImpact Journals, LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectTGFBR2
dc.subjectbiomarkers
dc.subjectgenetic variation
dc.subjectimmunosuppression
dc.subjectovarian cancer
dc.subjectAdenocarcinoma, Clear Cell
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectGene Frequency
dc.subjectGenetic Predisposition to Disease
dc.subjectGenotype
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectNeoplasms, Glandular and Epithelial
dc.subjectOvarian Neoplasms
dc.subjectPolymorphism, Single Nucleotide
dc.subjectProtein-Serine-Threonine Kinases
dc.subjectReceptors, Transforming Growth Factor beta
dc.subjectRisk Factors
dc.subjectT-Lymphocytes, Regulatory
dc.titleAssessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
dc.typeArticle
prism.endingPage69110
prism.issueIdentifier43
prism.publicationDate2016
prism.publicationNameOncotarget
prism.startingPage69097
prism.volume7
dc.identifier.doi10.17863/CAM.33250
dcterms.dateAccepted2016-05-29
rioxxterms.versionofrecord10.18632/oncotarget.10215
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-10-25
dc.contributor.orcidDennis, Joe [0000-0003-4591-1214]
dc.contributor.orcidDicks, Ed [0000-0002-0617-0401]
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.contributor.orcidSong, Honglin [0000-0001-5076-7371]
dc.contributor.orcidTyrer, Jonathan [0000-0003-3724-4757]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.identifier.eissn1949-2553
rioxxterms.typeJournal Article/Review
pubs.funder-project-idNational Cancer Institute (U19CA148537)
pubs.funder-project-idNational Cancer Institute (R01CA128978)
pubs.funder-project-idCancer Research Uk (None)
pubs.funder-project-idEuropean Commission (223175)
pubs.funder-project-idCancer Research UK (A10118)
cam.issuedOnline2016-06-21


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International