Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering.
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Authors
Curran, Scott
Strandkvist, Charlotte
Bathmann, Jasper
de Gennes, Marc
Salbreux, Guillaume
Baum, Buzz
Publication Date
2017-11-20Journal Title
Dev Cell
ISSN
1534-5807
Publisher
Elsevier BV
Volume
43
Issue
4
Pages
480-492.e6
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Curran, S., Strandkvist, C., Bathmann, J., de Gennes, M., Kabla, A., Salbreux, G., & Baum, B. (2017). Myosin II Controls Junction Fluctuations to Guide Epithelial Tissue Ordering.. Dev Cell, 43 (4), 480-492.e6. https://doi.org/10.1016/j.devcel.2017.09.018
Abstract
Under conditions of homeostasis, dynamic changes in the length of individual adherens junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the face of intrinsic and extrinsic forces. While the contribution of AJ remodeling to developmental morphogenesis has been intensively studied, less is known about AJ dynamics in other circumstances. Here, we study AJ dynamics in an epithelium that undergoes a gradual increase in packing order, without concomitant large-scale changes in tissue size or shape. We find that neighbor exchange events are driven by stochastic fluctuations in junction length, regulated in part by junctional actomyosin. In this context, the developmental increase of isotropic junctional actomyosin reduces the rate of neighbor exchange, contributing to tissue order. We propose a model in which the local variance in tension between junctions determines whether actomyosin-based forces will inhibit or drive the topological transitions that either refine or deform a tissue.
Keywords
Epithelium, Adherens Junctions, Animals, Drosophila melanogaster, Myosin Type II, Actomyosin, Cadherins, Drosophila Proteins
Identifiers
External DOI: https://doi.org/10.1016/j.devcel.2017.09.018
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285931
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