Integrated plug flow synthesis and crystallisation of pyrazinamide

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Authors
Scott, C Daniel
  Labes, Ricardo
Depardieu, Matrin J
  Battilocchio, Claudio
Davidson, Matthew G
Ley, Steven V
Wilson, Chick C
Publication Date
2018
Journal Title
Reaction Chemistry & Engineering
ISSN
2058-9883
Publisher
Royal Society of Chemistry
Volume
3
Pages
631-634
Type
Article
Metadata
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Citation
Scott, C. D., Labes, R., Depardieu, M. J., Battilocchio, C., Davidson, M. G., Ley, S. V., Wilson, C. C., & et al. (2018). Integrated plug flow synthesis and crystallisation of pyrazinamide. Reaction Chemistry & Engineering, 3 631-634. https://doi.org/10.1039/C8RE00087E
Abstract
We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics. Graphical abstract: Integrated plug flow synthesis and crystallisation of pyrazinamide
Sponsorship
The authors would like to acknowledge the EPSRC Centre for Doctoral Training in Sustainable Chemical Technologies (EP/L016354/1, Davidson, Scott) for funding ... At Cambridge we acknowledge the EPSRC (EP/K009494/1 and EP/K039520/1) for support (Ley).
Funder references
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/P006965/1)
Identifiers
External DOI: https://doi.org/10.1039/C8RE00087E
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285943
Rights
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International