Pathophysiology of Placenta Accreta Spectrum Disorders: A Review of Current Findings.
Burton, Graham J
Clin Obstet Gynecol
Ovid Technologies (Wolters Kluwer Health)
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Jauniaux, E., & Burton, G. J. (2018). Pathophysiology of Placenta Accreta Spectrum Disorders: A Review of Current Findings.. Clin Obstet Gynecol, 61 (4), 743-754. https://doi.org/10.1097/GRF.0000000000000392
Current findings continue to support the concept of a biologically defective decidua rather than a primarily abnormally invasive trophoblast. Prior cesarean sections increase the risk of placenta previa and both adherent and invasive placenta accreta, suggesting that the endometrial/decidual defect following the iatrogenic creation of a uterine myometrium scar has an adverse effect on early implantation. Preferential attachment of the blastocyst to scar tissue facilitates abnormally deep invasion of trophoblastic cells and interactions with the radial and arcuate arteries. Subsequent high velocity maternal arterial inflow into the placenta creates large lacunae, destroying the normal cotyledonary arrangement of the villi.
Myometrium, Decidua, Cicatrix, Trophoblasts, Humans, Placenta Accreta, Ultrasonography, Prenatal, Cesarean Section, Pregnancy, Placental Circulation, Female, Placenta Previa, Uterine Artery
External DOI: https://doi.org/10.1097/GRF.0000000000000392
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285957