Pathophysiology of Placenta Accreta Spectrum Disorders: A Review of Current Findings.
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Authors
Jauniaux, Eric
Burton, Graham J
Publication Date
2018-12Journal Title
Clin Obstet Gynecol
ISSN
0009-9201
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
61
Issue
4
Pages
743-754
Language
eng
Type
Article
Physical Medium
Print
Metadata
Show full item recordCitation
Jauniaux, E., & Burton, G. J. (2018). Pathophysiology of Placenta Accreta Spectrum Disorders: A Review of Current Findings.. Clin Obstet Gynecol, 61 (4), 743-754. https://doi.org/10.1097/GRF.0000000000000392
Abstract
Current findings continue to support the concept of a biologically defective decidua rather than a primarily abnormally invasive trophoblast. Prior cesarean sections increase the risk of placenta previa and both adherent and invasive placenta accreta, suggesting that the endometrial/decidual defect following the iatrogenic creation of a uterine myometrium scar has an adverse effect on early implantation. Preferential attachment of the blastocyst to scar tissue facilitates abnormally deep invasion of trophoblastic cells and interactions with the radial and arcuate arteries. Subsequent high velocity maternal arterial inflow into the placenta creates large lacunae, destroying the normal cotyledonary arrangement of the villi.
Keywords
Myometrium, Decidua, Cicatrix, Trophoblasts, Humans, Placenta Accreta, Ultrasonography, Prenatal, Cesarean Section, Pregnancy, Placental Circulation, Female, Placenta Previa, Uterine Artery
Identifiers
External DOI: https://doi.org/10.1097/GRF.0000000000000392
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285957
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Licence:
http://www.rioxx.net/licenses/all-rights-reserved
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