Dad's diet: smRNA methylation signatures in sperm pass on metabolic disease risk
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Authors
Ferguson-Smith, AC
Mashoodh, Rahia
Publication Date
2018-08Alternative Title
Dad's diet: smRNA methylation signatures in sperm pass on metabolic disease risk
Journal Title
Nature Reviews Endocrinology
ISSN
1759-5037
Publisher
Springer Nature
Volume
14
Pages
446-447
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Ferguson-Smith, A., & Mashoodh, R. (2018). Dad's diet: smRNA methylation signatures in sperm pass on metabolic disease risk. Nature Reviews Endocrinology, 14 446-447. https://doi.org/10.1038/s41574-018-0051-z
Abstract
The rapid rise in the incidence of obesity and associated metabolic disorders is a major public health challenge. Moreover, the frequency of disease risk has increased by an order of magnitude within a few decades. Despite our awareness that metabolic disease arises at the interface between genetic susceptibility and environmental factors (such as overnutrition and inactivity), we have not been able to curb the incidence of these disorders. With the advent of cost-effective whole-genome sequencing technologies has come the search for the genetic underpinnings of metabolic disorders; however, to date, only a small percentage of metabolic disease risk has been associated with genetic variants. This weak association with genetic variants has raised the intriguing possibility that metabolic disease risk could be transmitted from generation to generation via potentially modifiable non-genetic signals present in parental germ cells.
Keywords
Genetics, Nutrition, Prevention, 2.1 Biological and endogenous factors, 2 Aetiology, Metabolic and endocrine, Diet, Humans, Male, Metabolic Diseases, Methylation, RNA, Small Untranslated, Spermatozoa
Sponsorship
Medical Research Council (MR/J001597/1)
Wellcome Trust (095606/Z/11/Z)
Identifiers
External DOI: https://doi.org/10.1038/s41574-018-0051-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/285964
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http://www.rioxx.net/licenses/all-rights-reserved
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