Research data supporting "Effects of Reaction pH on Self-Crosslinked Chitosan-Carrageenan Polyelectrolyte Complex Gels and Sponges"
dc.contributor.author | Al-Zebari, Nawar | |
dc.contributor.author | Best, Serena | |
dc.contributor.author | Cameron, Ruth | |
dc.date.accessioned | 2018-11-26T16:43:45Z | |
dc.date.available | 2018-11-26T16:43:45Z | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/285988 | |
dc.description | Macromolecular biomaterials often require covalent crosslinking to achieve adequate stability for their given application. However, the use of auxiliary chemicals may be associated with long-term toxicity in the body. Oppositely-charged polyelectrolytes (PEs) have the advantage that they can self-crosslink electrostatically and those derived from marine organisms such as chitosan (CS) and carrageenan (CRG) are inexpensive non-toxic alternatives to glycosaminoglycans present in the extracellular matrix of human tissues. The aim of this study was to explore the properties of crosslinker-free PEC gels and freeze-dried PEC sponges based on CS and CRG precursors. We offer new insights into the optimisation of conditions and mechanisms involved in the process and offer a systematic study of property changes across a full range of pH values. Zeta potential measurements indicated that the PECs produced at pH 2-6 had a high strength of electrostatic interaction with the highest being at pH 4-5. This resulted in strong intra-crosslinking in the PEC gels which led to the formation of higher yield, viscosity, fibre content and lower moisture content. The weaker interaction between CS and CRG at pH 7-12 resulted in higher levels of CS incorporated into the complex and the formation of more inter-crosslinking through entanglements and secondary interactions between PEC units. This resulted in the production of stable PEC sponge materials compared with the PEC materials produced at pH 6 and below. From the range of samples tested, the PECs produced at pH 7.4 appeared to show the optimum combination of yield, stability and homogeneity. | |
dc.format | Microsoft Word, Microsoft Excel | |
dc.rights | Attribution 4.0 International (CC BY 4.0) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | chitosan | |
dc.subject | carageenan | |
dc.subject | polysaccharide | |
dc.subject | polyelectrolyte complex | |
dc.subject | self-crosslinking | |
dc.title | Research data supporting "Effects of Reaction pH on Self-Crosslinked Chitosan-Carrageenan Polyelectrolyte Complex Gels and Sponges" | |
dc.type | Dataset | |
dc.identifier.doi | 10.17863/CAM.30969 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0/ | |
datacite.contributor.supervisor | Cameron, Ruth Elizabeth | |
dcterms.format | .xlsx | |
dc.contributor.orcid | Best, Serena [0000-0001-7866-8607] | |
dc.contributor.orcid | Cameron, Ruth [0000-0003-1573-4923] | |
rioxxterms.type | Other | |
pubs.funder-project-id | European Research Council (320598) | |
datacite.issupplementto.doi | 10.1088/2515-7639/aae9ab |