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dc.contributor.authorMachado de Rezende, Leandro Fórnias
dc.contributor.authorTotaro Garcia, Leandro
dc.contributor.authorMielke, Grégore Iven
dc.contributor.authorHoon Lee, Dong
dc.contributor.authorWu, Kana
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorEluf-Neto, José
dc.date.accessioned2018-11-28T11:06:04Z
dc.date.available2018-11-28T11:06:04Z
dc.date.issued2018-10
dc.identifier.issn1877-7821
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286014
dc.description.abstractBackground: Physical activity is associated with lower risk of colon and breast cancers. Herein we estimated preventable fractions of colon and breast cancers in Brazil by increasing population-wide physical activity to different counterfactual scenarios. Methods: We used data from a representative national survey in Brazil and corresponding relative risks of colon and postmenopausal breast cancers from a meta-analysis. Estimated cancer incidence was retrieved from GLOBOCAN and Brazilian National Cancer Institute. Five counterfactual scenarios for physical activity were considered: (i) theoretical minimum risk exposure level (≥8,000 metabolic equivalent of tasks-minute/week – MET-min/week); (ii) physical activity recommendation (≥600 MET-min/week); (iii) a 10% reduction in prevalence of insufficient physical inactivity (<600 MET-min/week); (iv) physical activity level in each state equals the most active state in Brazil; (v) closing the gender differences in physical activity. Results: About 19% (3,630 cases) of colon cancers and 12% (6,712 cases) of postmenopausal breast cancers could be prevented by increasing physical activity to ≥8,000 MET-min/week. Plausible counterfactual scenarios suggested the following impact on cancer prevention: reaching physical activity recommendation: 1.3% (1,113 cases) of breast and 6% (1,137 cases) of colon; 10% reduction in physical inactivity prevalence: 0.2% (111 cases) of breast and 0.6% (114 cases) of colon; most active state scenario: 0.3% (168 cases) of breast and 1% (189 cases) of colon; reducing gender differences in physical activity: 1.1% (384 cases) of breast and 0.6% (122 cases) of colon. Conclusions: High levels of physical activity are required to achieve sizable impact on breast and colon cancer prevention in Brazil.
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titlePreventable fractions of colon and breast cancers by increasing physical activity in Brazil: perspectives from plausible counterfactual scenarios
dc.typeArticle
prism.endingPage45
prism.publicationNameCancer Epidemiology
prism.startingPage38
prism.volume56
dc.identifier.doi10.17863/CAM.33334
dcterms.dateAccepted2018-07-10
rioxxterms.versionofrecord10.1016/j.canep.2018.07.006
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2018-07-10
dc.contributor.orcidTotaro Garcia, Leandro [0000-0001-5947-2617]
dc.identifier.eissn1877-783X
dc.publisher.urlhttps://www.sciencedirect.com/science/article/pii/S1877782118303436?via=ihub
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/K023187/1)
pubs.funder-project-idEconomic and Social Research Council (ES/G007462/1)
pubs.funder-project-idWellcome Trust (087636/Z/08/Z)
pubs.funder-project-idMRC (MR/L501438/1)
cam.issuedOnline2018-07-19
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1877782118303436?via=ihub


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Attribution-NonCommercial-NoDerivatives 4.0 International
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