The molecular biology of feline immunodeficiency virus (FIV).
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Authors
Kenyon, Julia C
Lever, Andrew ML
Publication Date
2011-11Journal Title
Viruses
ISSN
1999-4915
Publisher
MDPI AG
Volume
3
Issue
11
Pages
2192-2213
Language
eng
Type
Article
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Kenyon, J. C., & Lever, A. M. (2011). The molecular biology of feline immunodeficiency virus (FIV).. Viruses, 3 (11), 2192-2213. https://doi.org/10.3390/v3112192
Abstract
Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-like illness in domestic cats. It is highly prevalent in several endangered feline species. In domestic cats FIV infection is a valuable small animal model for HIV infection. In recent years there has been sa significant increase in interest in FIV, in part to exploit this, but also because of the potential it has as a human gene therapy vector. Though much less studied than HIV there are many parallels in the replication of the two viruses, but also important differences and, despite their likely common origin, the viruses have in some cases used alternative strategies to overcome similar problems. Recent advances in understanding the structure and function of FIV RNA and proteins and their interactions has enhanced our knowledge of FIV replication significantly, however, there are still many gaps. This review summarizes our current knowledge of FIV molecular biology and its similarities with, and differences from, other lentiviruses.
Keywords
Animals, Cats, Humans, Immunodeficiency Virus, Feline, HIV, Feline Acquired Immunodeficiency Syndrome, HIV Infections, Virus Replication
Sponsorship
Wellcome Trust (078007/Z/05/Z)
Medical Research Council (G0800142)
Identifiers
External DOI: https://doi.org/10.3390/v3112192
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286131
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