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dc.contributor.authorScott, Kirsten Men
dc.contributor.authorKouli, Antoninaen
dc.contributor.authorYeoh, Su Len
dc.contributor.authorClatworthy, Mennaen
dc.contributor.authorWilliams-Gray, Carolineen
dc.date.accessioned2018-12-01T00:31:11Z
dc.date.available2018-12-01T00:31:11Z
dc.date.issued2018-01en
dc.identifier.issn1664-2295
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286214
dc.description.abstractImmune dysfunction has been associated with Parkinson’s disease (PD) and its progression. Antibodies play an important role in both innate and adaptive responses, acting as powerful effector molecules that can propagate inflammation by activating innate immune cells. Alpha synuclein binding antibodies have been described in PD patients with conflicting associations. In this article, we consider the potential mechanistic basis of alpha synuclein auto-antibody development and function in PD. We present a systematic review and meta-analysis of antibody studies in PD cohorts showing that there is weak evidence for an increase in alpha synuclein auto-antibodies in PD patients particularly in early disease. The confidence with which this conclusion can be drawn is limited by the heterogeneity of the clinical cohorts used, inclusion of unmatched controls, inadequate power and assay related variability. We have therefore made some recommendations for the design of future studies.
dc.description.sponsorshipWe received no specific funding for this work. KM Scott is supported by a PhD fellowship from the Wellcome Trust. CH Williams-Gray is supported by a Clinician Scientist fellowship from the Medical Research Council. MR Clatworthy is supported by a Medical Research Council New Investigator Research Grant (MR/N024907/1) and an Arthritis Research UK Cure Challenge Research Grant (21777). This work was also supported by the NIHR Cambridge Biomedical Research Centre.
dc.format.mediumElectronic-eCollectionen
dc.languageengen
dc.publisherFrontiers Media
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleA Systematic Review and Meta-Analysis of Alpha Synuclein Auto-Antibodies in Parkinson's Disease.en
dc.typeArticle
prism.publicationDate2018en
prism.publicationNameFrontiers in neurologyen
prism.startingPage815
prism.volume9en
dc.identifier.doi10.17863/CAM.33525
dcterms.dateAccepted2018-09-10en
rioxxterms.versionofrecord10.3389/fneur.2018.00815en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-01en
dc.contributor.orcidKouli, Antonina [0000-0001-6553-6154]
dc.contributor.orcidClatworthy, Menna [0000-0002-3340-9828]
dc.contributor.orcidWilliams-Gray, Caroline [0000-0002-2648-9743]
dc.identifier.eissn1664-2295
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (BRC)
pubs.funder-project-idWELLCOME TRUST (106565/Z/14/Z)
pubs.funder-project-idMRC (MR/R007446/1)
pubs.funder-project-idArthritis Research UK (21777)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International