Trajectories and Milestones of Cortical and Subcortical Development of the Marmoset Brain From Infancy to Adulthood.
Cerebral cortex (New York, N.Y. : 1991)
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Sawiak, S., Shiba, Y., Oikonomidis, L., Windle, C., Santangelo, A. M., Grydeland, H., Cockcroft, G., et al. (2018). Trajectories and Milestones of Cortical and Subcortical Development of the Marmoset Brain From Infancy to Adulthood.. Cerebral cortex (New York, N.Y. : 1991), 28 (12), 4440-4453. https://doi.org/10.1093/cercor/bhy256
With increasing attention on the developmental causes of neuropsychiatric disorders, appropriate animal models are crucial to identifying causes and assessing potential interventions. The common marmoset is an ideal model as it has sophisticated social/emotional behaviour, reaching adulthood within 2 years of birth. Magnetic resonance imaging was used in an accelerated longitudinal cohort (n=41; aged 3-27 months; scanned 2-7 times over 2 years). Splines were used to model non-linear trajectories of grey matter volume development in 53 cortical areas and 16 subcortical nuclei. Generally, volumes increased before puberty, peaked, and declined into adulthood. We identified three milestones of grey matter development: (i) age at peak volume; (ii) age at onset of volume decline; and (iii) age at maximum rate of volume decline. These milestones differentiated growth trajectories of primary sensory/motor cortical areas from those of association cortex but also revealed distinct trajectories between association cortices. Cluster analysis of trajectories showed that prefrontal cortex was the most heterogenous of association regions, comprising areas with distinct milestones and developmental trajectories. These results highlight the potential of high-field structural MRI to define the dynamics of primate brain development and importantly to identify when specific prefrontal circuits may be most vulnerable to environmental impact.
Brain, Animals, Callithrix, Magnetic Resonance Imaging, Models, Neurological, Female, Male, Gray Matter
WELLCOME TRUST (105602/Z/14/Z)
WELLCOME TRUST (108089/Z/15/Z)
Medical Research Council (MR/M023990/1)
MEDICAL RESEARCH COUNCIL (G0001354)
External DOI: https://doi.org/10.1093/cercor/bhy256
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286215
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/