Show simple item record

dc.contributor.authorSawiak, Stephenen
dc.contributor.authorShiba, Yen
dc.contributor.authorOikonomidis, Len
dc.contributor.authorWindle, CPen
dc.contributor.authorSantangelo, Andrea Marianaen
dc.contributor.authorGrydeland, Hen
dc.contributor.authorCockcroft, Gemmaen
dc.contributor.authorBullmore, Edwarden
dc.contributor.authorRoberts, Angelaen
dc.date.accessioned2018-12-01T00:31:13Z
dc.date.available2018-12-01T00:31:13Z
dc.date.issued2018-12en
dc.identifier.issn1047-3211
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286215
dc.description.abstractWith increasing attention on the developmental causes of neuropsychiatric disorders, appropriate animal models are crucial to identifying causes and assessing potential interventions. The common marmoset is an ideal model as it has sophisticated social/emotional behaviour, reaching adulthood within 2 years of birth. Magnetic resonance imaging was used in an accelerated longitudinal cohort (n=41; aged 3-27 months; scanned 2-7 times over 2 years). Splines were used to model non-linear trajectories of grey matter volume development in 53 cortical areas and 16 subcortical nuclei. Generally, volumes increased before puberty, peaked, and declined into adulthood. We identified three milestones of grey matter development: (i) age at peak volume; (ii) age at onset of volume decline; and (iii) age at maximum rate of volume decline. These milestones differentiated growth trajectories of primary sensory/motor cortical areas from those of association cortex but also revealed distinct trajectories between association cortices. Cluster analysis of trajectories showed that prefrontal cortex was the most heterogenous of association regions, comprising areas with distinct milestones and developmental trajectories. These results highlight the potential of high-field structural MRI to define the dynamics of primate brain development and importantly to identify when specific prefrontal circuits may be most vulnerable to environmental impact.
dc.format.mediumPrinten
dc.languageengen
dc.publisherOUP
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBrainen
dc.subjectAnimalsen
dc.subjectCallithrixen
dc.subjectMagnetic Resonance Imagingen
dc.subjectModels, Neurologicalen
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectGray Matteren
dc.titleTrajectories and Milestones of Cortical and Subcortical Development of the Marmoset Brain From Infancy to Adulthood.en
dc.typeArticle
prism.endingPage4453
prism.issueIdentifier12en
prism.publicationDate2018en
prism.publicationNameCerebral cortex (New York, N.Y. : 1991)en
prism.startingPage4440
prism.volume28en
dc.identifier.doi10.17863/CAM.33526
dcterms.dateAccepted2018-09-13en
rioxxterms.versionofrecord10.1093/cercor/bhy256en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-12en
dc.contributor.orcidSawiak, Stephen [0000-0003-4210-9816]
dc.contributor.orcidShiba, Y [0000-0002-4948-4646]
dc.contributor.orcidSantangelo, Andrea Mariana [0000-0001-7727-2651]
dc.contributor.orcidGrydeland, H [0000-0001-5061-464X]
dc.contributor.orcidBullmore, Edward [0000-0002-8955-8283]
dc.contributor.orcidRoberts, Angela [0000-0003-2873-157X]
dc.identifier.eissn1460-2199
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G1000183)
pubs.funder-project-idWELLCOME TRUST (105602/Z/14/Z)
pubs.funder-project-idWELLCOME TRUST (108089/Z/15/Z)
pubs.funder-project-idMedical Research Council (MR/M023990/1)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0001354)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International