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dc.contributor.authorFrye, Michaela
dc.contributor.authorHarada, Bryan T
dc.contributor.authorBehm, Mikaela
dc.contributor.authorHe, Chuan
dc.date.accessioned2018-12-04T00:30:35Z
dc.date.available2018-12-04T00:30:35Z
dc.date.issued2018-09-28
dc.identifier.issn0036-8075
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286245
dc.description.abstractRNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA (mRNA) modifications regulate various aspects of mRNA metabolism. For example, N 6-methyladenosine (m6A) affects the translation and stability of the modified transcripts, thus providing a mechanism to coordinate the regulation of groups of transcripts during cell state maintenance and transition. Similarly, some modifications in transfer RNAs are essential for RNA structure and function. Others are deposited in response to external cues and adapt global protein synthesis and gene-specific translational accordingly and thereby facilitate proper development.
dc.description.sponsorshipB.T.H is supported by National Cancer Institute fellowship F32 CA221007. C.H. is supported by National Institute of Health (HG008935 and GM071440). C.H. is an investigator of the Howard Hughes Medical Institute. M.F. is supported by a Cancer Research UK Senior Fellowship (C10701/A15181), the European Research Council (ERC; 310360), and the Medical Research Council UK (MR/M01939X/1). Part of this work was carried out in the framework of the European COST action EPITRAN 16120.
dc.format.mediumPrint
dc.languageeng
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectDisease
dc.subjectMethyltransferases
dc.subjectRNA, Messenger
dc.subjectRNA, Ribosomal
dc.subjectRNA, Transfer
dc.subjectAdenosine
dc.subjectCell Differentiation
dc.subjectTranscription, Genetic
dc.subjectGene Expression Regulation, Developmental
dc.subjectRNA Processing, Post-Transcriptional
dc.titleRNA modifications modulate gene expression during development.
dc.typeArticle
prism.endingPage1349
prism.issueIdentifier6409
prism.publicationDate2018
prism.publicationNameScience
prism.startingPage1346
prism.volume361
dc.identifier.doi10.17863/CAM.27741
dcterms.dateAccepted2018-09-14
rioxxterms.versionofrecord10.1126/science.aau1646
rioxxterms.versionNA
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-09
dc.contributor.orcidFrye, Michaela [0000-0002-5636-6840]
dc.contributor.orcidHarada, Bryan T [0000-0002-9683-782X]
dc.contributor.orcidBehm, Mikaela [0000-0002-3272-1377]
dc.contributor.orcidHe, Chuan [0000-0003-4319-7424]
dc.identifier.eissn1095-9203
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_PC_12009)
pubs.funder-project-idMedical Research Council (MR/M01939X/1)
pubs.funder-project-idEuropean Research Council (310360)
rioxxterms.freetoread.startdate2019-03-28


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