Different Effects of Vascular Aging on Ischemic Predisposition in Healthy Men and Women.
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Authors
Namasivayam, Mayooran
Yasmin
Cockroft, John R
McDonnell, Barry J
Adji, Audrey
O'Rourke, Michael F
Publication Date
2018-12Journal Title
Hypertension
ISSN
0194-911X
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
72
Issue
6
Pages
1294-1300
Language
eng
Type
Article
Physical Medium
Print
Metadata
Show full item recordCitation
Namasivayam, M., McEniery, C., Wilkinson, I., Yasmin, Cockroft, J. R., McDonnell, B. J., Adji, A., & et al. (2018). Different Effects of Vascular Aging on Ischemic Predisposition in Healthy Men and Women.. Hypertension, 72 (6), 1294-1300. https://doi.org/10.1161/HYPERTENSIONAHA.118.11642
Abstract
Invasive studies of the twentieth century showed the value of aortic pressure-time integrals as markers of myocardial oxygen demand and supply. More recent studies have used these concepts to evaluate the mechanisms of ischemic predisposition using noninvasive arterial tonometry in cardiology outpatients. We sought to evaluate the spectrum of myocardial oxygen demand and supply in a large cross-sectional community sample of healthy volunteers and identify the roles of age, sex, and wave reflection. Arterial tonometry was performed in 3682 healthy volunteers. Measures of systolic and diastolic pressure-time integrals and their ratio in addition to cardiac ejection duration were determined and analyzed by age and sex. Multiple regression analyses were performed to identify the mechanisms underlying observations, while controlling for confounders (heart rate, height, weight, and mean pressure). In a healthy cohort, older women more than men ( P<0.001) had unfavorable myocardial oxygen supply:demand ratios because of differing effects of vascular aging.
Keywords
Humans, Cross-Sectional Studies, Manometry, Sex Factors, Aging, Blood Pressure, Adult, Aged, Middle Aged, Female, Male, Hemodynamics, Vascular Stiffness
Sponsorship
Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
British Heart Foundation (None)
British Heart Foundation (None)
British Heart Foundation (None)
Identifiers
External DOI: https://doi.org/10.1161/HYPERTENSIONAHA.118.11642
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286248
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