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dc.contributor.authorNestor, Liam J
dc.contributor.authorPaterson, Louise M
dc.contributor.authorMurphy, Anna
dc.contributor.authorMcGonigle, John
dc.contributor.authorOrban, Csaba
dc.contributor.authorReed, Laurence
dc.contributor.authorTaylor, Eleanor
dc.contributor.authorFlechais, Remy
dc.contributor.authorSmith, Dana
dc.contributor.authorBullmore, Edward T
dc.contributor.authorErsche, Karen D
dc.contributor.authorSuckling, John
dc.contributor.authorElliott, Rebecca
dc.contributor.authorDeakin, Bill
dc.contributor.authorRabiner, Ilan
dc.contributor.authorLingford Hughes, Anne
dc.contributor.authorSahakian, Barbara J
dc.contributor.authorRobbins, Trevor W
dc.contributor.authorNutt, David J
dc.contributor.authorICCAM Consortium
dc.date.accessioned2018-12-04T00:30:43Z
dc.date.available2018-12-04T00:30:43Z
dc.date.issued2019-08
dc.identifier.issn0953-816X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286250
dc.description.abstractIdentifying key neural substrates in addiction disorders for targeted drug development remains a major challenge for clinical neuroscience. One emerging target is the opioid system, where substance-dependent populations demonstrate prefrontal opioid dysregulation that predicts impulsivity and relapse. This may suggest that disturbances to the prefrontal opioid system could confer a risk for relapse in addiction due to weakened 'top-down' control over impulsive behaviour. Naltrexone is currently licensed for alcohol dependence and is also used clinically for impulse control disorders. Using a go/no-go (GNG) task, we examined the effects of acute naltrexone on the neural correlates of successful motor impulse control in abstinent alcoholics (AUD), abstinent polysubstance-dependent (poly-SUD) individuals and controls during a randomised double blind placebo controlled fMRI study. In the absence of any differences on GNG task performance, the AUD group showed a significantly greater BOLD response compared to the control group in lateral and medial prefrontal regions during both placebo and naltrexone treatments; effects that were positively correlated with alcohol abstinence. There was also a dissociation in the positive modulating effects of naltrexone in the orbitofrontal cortex (OFC) and anterior insula cortex (AIC) of the AUD and poly-SUD groups respectively. Self-reported trait impulsivity in the poly-SUD group also predicted the effect of naltrexone in the AIC. These results suggest that acute naltrexone differentially amplifies neural responses within two distinct regions of a salience network during successful motor impulse control in abstinent AUD and poly-SUD groups, which are predicted by trait impulsivity in the poly-SUD group.
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This article presents independent research funded by the MRC as part of their addiction initiative (grant number G1000018). GSK kindly funded the functional and structural MRI scans that took place at the London site for this study.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectICCAM Consortium
dc.subjectHumans
dc.subjectSubstance-Related Disorders
dc.subjectAlcoholism
dc.subjectNaltrexone
dc.subjectAlcohol Deterrents
dc.subjectMagnetic Resonance Imaging
dc.subjectDouble-Blind Method
dc.subjectImpulsive Behavior
dc.subjectPsychomotor Performance
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectAlcohol Abstinence
dc.titleNaltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and polysubstance-dependent individuals.
dc.typeArticle
prism.endingPage2321
prism.issueIdentifier3
prism.publicationDate2019
prism.publicationNameEur J Neurosci
prism.startingPage2311
prism.volume50
dc.identifier.doi10.17863/CAM.33562
dcterms.dateAccepted2018-09-21
rioxxterms.versionofrecord10.1111/ejn.14262
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-08
dc.contributor.orcidNestor, Liam J [0000-0002-8854-9908]
dc.identifier.eissn1460-9568
rioxxterms.typeJournal Article/Review
cam.issuedOnline2018-11-26


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International