Statistical theory of branching morphogenesis.
Development, growth & differentiation
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Hannezo, E., & Simons, B. (2018). Statistical theory of branching morphogenesis.. Development, growth & differentiation, 60 (9), 512-521. https://doi.org/10.1111/dgd.12570
Branching morphogenesis remains a subject of abiding interest. Although much is known about the gene regulatory programs and signaling pathways that operate at the cellular scale, it has remained unclear how the macroscopic features of branched organs, including their size, network topology and spatial patterning, are encoded. Lately, it has been proposed that, these features can be explained quantitatively in several organs within a single unifying framework. Based on large-scale organ reconstructions and cell lineage tracing, it has been argued that morphogenesis follows from the collective dynamics of sublineage-restricted self-renewing progenitor cells, localized at ductal tips, that act cooperatively to drive a serial process of ductal elongation and stochastic tip bifurcation. By correlating differentiation or cell cycle exit with proximity to maturing ducts, this dynamics results in the specification of a complex network of defined density and statistical organization. These results suggest that, for several mammalian tissues, branched epithelial structures develop as a self-organized process, reliant upon a strikingly simple, but generic, set of local rules, without recourse to a rigid and deterministic sequence of genetically programmed events. Here we review the basis of these findings and discuss their implications.
Pancreas, Kidney, Epithelium, Epithelial Cells, Animals, Humans, Cell Proliferation, Cell Lineage, Morphogenesis, Models, Biological
WELLCOME TRUST (098357/Z/12/Z)
Wellcome Trust (092096/Z/10/Z)
Cancer Research UK (A14492)
External DOI: https://doi.org/10.1111/dgd.12570
This record's URL: https://www.repository.cam.ac.uk/handle/1810/286253
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/