Show simple item record

dc.contributor.authorMezquida, Gisela
dc.contributor.authorFernandez-Egea, Emilio
dc.contributor.authorTreen, Devi
dc.contributor.authorMané, Anna
dc.contributor.authorBergé, Daniel
dc.contributor.authorSavulich, George
dc.contributor.authorGarcia-Alvarez, Leticia
dc.contributor.authorGarcía-Portilla, Paz
dc.contributor.authorBobes, Julio
dc.contributor.authorBernardo, Miguel
dc.contributor.authorGarcia-Rizo, Clemente
dc.date.accessioned2018-12-04T00:31:22Z
dc.date.available2018-12-04T00:31:22Z
dc.date.issued2018-11
dc.identifier.issn0022-3018
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286272
dc.description.abstractSchizophrenia is a complex mental disorder with genetic and environmental components. Obstetric complications (OCs) are one of the most common environmental risk factors described. However, despite being different in timing and outcome, OCs are usually described as a homogeneous entity. In the present study, we evaluate the presence of different patterns of OCs evaluated with the Lewis-Murray Scale in chronic schizophrenia patients (n = 101) and their association with a crude marker of the intrauterine environment such as weight at birth.OCs related with abnormal fetal growth (p < 0.001) and OCs during gestation (p = 0.003) were associated with lower birth weight. However, difficulties in delivery, complications in pregnancy, and OCs all together (as a set) were not associated with weight at birth.Our results infer that OCs cannot be taken as a homogeneous group. Different patterns of OCs result in different birth weights, which is associated with specific metabolic, cognitive, and brain structure outcomes.
dc.description.sponsorshipThis work was supported by the Government of Catalonia, Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2014SGR441), with the grants FI-DGR-2013 Contract of the Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) (2015 FI_B2 00100) and from Fundació Bosch Gimpera (FBG) within the RETOS COLABORACIÓN 2015, funded by the Spanish Ministry of Economic Affairs and Competitiveness (RTC-2015-3440-1) to G. Mezquida. Dr. Bernardo has been supported by research funding from the Spanish Ministry of Health, the Spanish Ministry of Science and Education, the Spanish Ministry of Economic Affairs and Competitiveness, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), by Secretaria d'Universitat i Recerca del Departament d'Economia I Coneixement (2014SGR441), Foundation European Group for Research In Schizophrenia (EGRIS), and the 7th Framework Program of the European Union. Dr. Garcia-Rizo is supported by the PI14/00753 project, integrated into the State Plan of Scientific and Technical Research and Innovation 2013–2016 and co-financed by the ISCIII-General Evaluation Branch and the European Regional Development Fund (ERDF). Dr. Bobes is supported by the Spanish Ministry of Health, the Spanish Ministry of Science and Education, the Spanish Ministry of Economic Affairs and Competitiveness and CIBERSAM. Dr. Paz-Portilla has been also supported by the European Commission, ISCIII-General Evaluation Branch and CIBERSAM. Dr. Savulich is funded by a grant from Eton College and theWallitt Foundation. Dr. Fernanez-Egea is supported, in part, by the NIRH-Biomedical Research Center, Cambridge.
dc.format.mediumPrint
dc.languageeng
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.subjectHumans
dc.subjectPregnancy Complications
dc.subjectFetal Growth Retardation
dc.subjectBirth Weight
dc.subjectRisk Factors
dc.subjectCross-Sectional Studies
dc.subjectSchizophrenia
dc.subjectPregnancy
dc.subjectPhenotype
dc.subjectAdult
dc.subjectFemale
dc.subjectObstetric Labor Complications
dc.subjectMale
dc.titleObstetric Phenotypes in the Heterogeneity of Schizophrenia.
dc.typeArticle
prism.endingPage886
prism.issueIdentifier11
prism.publicationDate2018
prism.publicationNameJ Nerv Ment Dis
prism.startingPage882
prism.volume206
dc.identifier.doi10.17863/CAM.33584
dcterms.dateAccepted2018-09-18
rioxxterms.versionofrecord10.1097/NMD.0000000000000897
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-11
dc.contributor.orcidBergé, Daniel [0000-0003-2544-1016]
dc.contributor.orcidBobes, Julio [0000-0003-2187-4033]
dc.contributor.orcidBernardo, Miguel [0000-0001-8748-6717]
dc.contributor.orcidGarcia-Rizo, Clemente [0000-0002-4855-1608]
dc.identifier.eissn1539-736X
rioxxterms.typeJournal Article/Review
rioxxterms.freetoread.startdate2019-11-30


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record