Show simple item record

dc.contributor.authorWolpe, Noham
dc.contributor.authorZhang, Jiaxiang
dc.contributor.authorNombela, Cristina
dc.contributor.authorIngram, James N
dc.contributor.authorWolpert, Daniel
dc.contributor.authorCam-CAN
dc.contributor.authorRowe, James
dc.date.accessioned2018-12-04T00:31:28Z
dc.date.available2018-12-04T00:31:28Z
dc.date.issued2018-10-23
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286276
dc.description.abstractAbnormal initiation and control of voluntary movements are among the principal manifestations of Parkinson's disease (PD). However, the processes underlying these abnormalities and their potential remediation by dopamine treatment remain poorly understood. Normally, movements depend on the integration of sensory information with the predicted consequences of action. This integration leads to a suppression in the intensity of predicted sensations, reflected in a 'sensory attenuation'. We examined this integration process and its relation to dopamine in PD, by measuring sensory attenuation. Patients with idiopathic PD (n = 18) and population-derived controls (n = 175) matched a set of target forces applied to their left index finger by a torque motor. To match the force, participants either pressed with their right index finger ('Direct' condition) or moved a knob that controlled a motor through a linear potentiometer ('Slider' condition). We found that despite changes in sensitivity to different forces, overall sensory attenuation did not differ between medicated PD patients and controls. Importantly, the degree of attenuation was negatively related to PD motor severity but positively related to individual patient dopamine dose, as measured by levodopa dose equivalent. The results suggest that dopamine could regulate the integration of sensorimotor prediction with sensory information to facilitate the control of voluntary movements.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCam-CAN
dc.subjectHumans
dc.subjectParkinson Disease
dc.subjectDopamine
dc.subjectSeverity of Illness Index
dc.subjectCase-Control Studies
dc.subjectTask Performance and Analysis
dc.subjectSensation
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.titleSensory attenuation in Parkinson's disease is related to disease severity and dopamine dose.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2018
prism.publicationNameSci Rep
prism.startingPage15643
prism.volume8
dc.identifier.doi10.17863/CAM.33588
dcterms.dateAccepted2018-09-25
rioxxterms.versionofrecord10.1038/s41598-018-33678-3
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2018-10-23
dc.contributor.orcidWolpe, Noham [0000-0002-4652-7727]
dc.contributor.orcidZhang, Jiaxiang [0000-0002-4758-0394]
dc.contributor.orcidNombela, Cristina [0000-0002-9806-2351]
dc.contributor.orcidIngram, James N [0000-0003-2567-504X]
dc.contributor.orcidWolpert, Daniel [0000-0003-2011-2790]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (103838/Z/14/Z)
pubs.funder-project-idWellcome Trust (097803/Z/11/Z)
pubs.funder-project-idRoyal Society (RP120142)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/H008217/1)
pubs.funder-project-idMedical Research Council (MC_U105597119)
pubs.funder-project-idMedical Research Council (MC_UU_00005/12)
cam.issuedOnline2018-10-23


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International