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dc.contributor.authorHanly, JG
dc.contributor.authorLi, Q
dc.contributor.authorSu, L
dc.contributor.authorUrowitz, MB
dc.contributor.authorGordon, C
dc.contributor.authorBae, SC
dc.contributor.authorRomero-Diaz, J
dc.contributor.authorSanchez-Guerrero, J
dc.contributor.authorBernatsky, S
dc.contributor.authorClarke, AE
dc.contributor.authorWallace, DJ
dc.contributor.authorIsenberg, DA
dc.contributor.authorRahman, A
dc.contributor.authorMerrill, JT
dc.contributor.authorFortin, PR
dc.contributor.authorGladman, DD
dc.contributor.authorBruce, IN
dc.contributor.authorPetri, M
dc.contributor.authorGinzler, E
dc.contributor.authorDooley, MA
dc.contributor.authorSteinsson, K
dc.contributor.authorRamsey-Goldman, R
dc.contributor.authorZoma, AA
dc.contributor.authorManzi, S
dc.contributor.authorNived, O
dc.contributor.authorJonsen, A
dc.contributor.authorKhamashta, MA
dc.contributor.authorAlarcón, GS
dc.contributor.authorvan Vollenhoven, RF
dc.contributor.authorAranow, C
dc.contributor.authorMackay, M
dc.contributor.authorRuiz-Irastorza, G
dc.contributor.authorRamos-Casals, M
dc.contributor.authorLim, SS
dc.contributor.authorInanc, M
dc.contributor.authorKalunian, KC
dc.contributor.authorJacobsen, S
dc.contributor.authorPeschken, CA
dc.contributor.authorKamen, DL
dc.contributor.authorAskanase, A
dc.contributor.authorTheriault, C
dc.contributor.authorFarewell, V
dc.date.accessioned2018-12-04T00:31:39Z
dc.date.available2018-12-04T00:31:39Z
dc.date.issued2019
dc.identifier.issn2326-5191
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286281
dc.description.abstractObjectives: To determine, in a multi-ethnic/racial, prospective SLE inception cohort, the frequency, attribution, clinical and autoantibody associations with lupus psychosis and the short and long-term outcome as assessed by physicians and patients. Methods: Patients were evaluated annually for 19 neuropsychiatric (NP) events including psychosis. SLE disease activity 2000, SLICC/ACR damage index and SF-36 scores were collected. Time to event and linear regressions were used as appropriate. Results: Of 1,826 SLE patients, 88.8% were female, 48.8% Caucasian. The meanSD age was 35.1±13.3 years, disease duration 5.64.2 months and follow-up 7.44.5 years. There were 31 psychotic events in 28/1,826 (1.53%) patients and most [(26/28; 93%)] had a single event. In the majority of patients [20/25; (80%)] and events [28/31; (90%)] psychosis was attributed to SLE, usually within 3 years of SLE diagnosis. Positive associations [hazard ratio and 95% confidence interval [HR (95%CI)] with lupus psychosis were prior SLE NP events [3.59, (1.16, 11.14), male sex [3.0, (1.20, 7.50)], younger age at SLE diagnosis [(per 10 years younger), 1.45 (1.01, 2.07)] and African ancestry [4.59 (1.79, 11.76)]. By physician assessment most psychotic events resolved by the second annual visit following onset, in parallel with an improvement in patient reported SF-36 summary and subscale scores. Conclusion: Psychosis is an infrequent manifestation of NPSLE. Generally, it occurs early after SLE onset and has a significant negative impact on health status. As determined by patient and physician report, the short and long term outlook is good for most patients, though careful follow-up is required.
dc.publisherWiley
dc.titlePsychosis in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
dc.typeArticle
prism.endingPage289
prism.issueIdentifier2
prism.publicationDate2019
prism.publicationNameArthritis and Rheumatology
prism.startingPage281
prism.volume71
dc.identifier.doi10.17863/CAM.33593
dcterms.dateAccepted2018-09-28
rioxxterms.versionofrecord10.1002/art.40764
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2019-02-01
dc.contributor.orcidPetri, M [0000-0003-1441-5373]
dc.identifier.eissn2326-5205
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (unknown)
pubs.funder-project-idMRC (unknown)
cam.issuedOnline2019-01-18
rioxxterms.freetoread.startdate2019-09-30


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